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Synfacts 2008(11): 1134-1134
DOI: 10.1055/s-0028-1083416
DOI: 10.1055/s-0028-1083416
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of ()-Platencin
J. Hayashida, V. H. Rawal*
the University of Chicago, USA
Further Information
Publication History
Publication Date:
23 October 2008 (online)
Significance
Platencin is isolated from Streptomycis platensis MA7339. Platencin combats methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and Streptococcus pneumoniae. Platencin structurally resembles platensimycin and inhibits the fatty acids synthesis pathway in bacteria by binding with the initiation- condensing and elongation-condensing enzymes FabH and FabF/B.