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Synfacts 2008(11): 1128-1128  
DOI: 10.1055/s-0028-1083414
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Minfiensine

Contributor(s): Philip Kocienski, Zofia Komsta
A. B. Dounay, P. G. Humphreys, L. E. Overman*, A. D. Wrobleski
University of California, Irvine, USA
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

Minfiensine is isolated from the African plant Strychnos minfiensis. The authors present two strategies for conversion of the intermediate F into the target molecule. The markworthy step of the synthesis is a tandem enantioselective intramolecular Heck iminium ion cyclization (C → E → F). For another recent synthesis of ()-minfiensine see: L. Shen, M. Zhang, Y. Wu, Y. Qin, ­Angew. Chem. Int. Ed. 2008, 47, 3618.