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Synfacts 2008(11): 1136-1136  
DOI: 10.1055/s-0028-1083408
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ()-Axinellamines A and B

Contributor(s): Philip Kocienski
D. P. O’Malley, J. Yamaguchi, I. S. Young, I. B. Seiple, P. S. Baran*
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

The presence of eight contiguous stereogenic centers, 10 nitrogen atoms and two guanidine residues makes the axinellamines a masochist’s delight. The Baran group’s synthesis features remarkably chemoselective oxidation and acylation of complex unprotected polyamines.