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Synfacts 2008(11): 1225-1225  
DOI: 10.1055/s-0028-1083401
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Sonogashira Coupling with Pd/C

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
S. Mori, T. Yanase, S. Aoyagi, Y. Monguchi, T. Maegawa, H. Sajiki*
Gifu Pharmaceutical University, Japan
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

The Sonogashira coupling reaction of aryl iodides 1 with terminal alkynes 2 was achieved by using Pd/C as a catalyst without a ligand, copper salt, or amine. The reaction was carried out in the presence of 0.4 mol% Pd of 10% Pd/C and Na3PO4˙12H2O under an argon atmosphere to give the corresponding internal alkynes 3 in 38-96% yield (20 examples).