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Synfacts 2008(11): 1223-1223  
DOI: 10.1055/s-0028-1083382
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Organocatalytic Mannich and Biginelli Reaction in Total Synthesis

Contributor(s): Benjamin List, Lars Ratjen
J. M. Goss, S. E. Schaus*
Boston University, USA
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

The concise synthesis of SNAP-7941, a chiral dihydropyrimidone is reported. The procedure involves an organocatalytic key step to optically pure intermediate 1. Two approaches, a cinchona alkaloid catalyzed Mannich reaction and a chiral phosphoric acid catalyzed Biginelli reaction proved to be highly useful for this synthesis.