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Synthesis 2009(5): 715-720
DOI: 10.1055/s-0028-1083359
DOI: 10.1055/s-0028-1083359
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Novel and Efficient Synthesis of Dihydrexidine
Further Information
Received
25 September 2008
Publication Date:
11 February 2009 (online)
Publication History
Publication Date:
11 February 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200905/lookinside/thumbnails/10.1055-s-0028-1083359-1.jpg)
Abstract
An efficient synthesis of the dopamine D1 selective full agonist dihydrexidine has been achieved in high yields and requiring no chromatographic separations via a facilitated intramolecular Henry cyclization of a (nitropropyl)benzophenone and subsequent diastereomerically selective reduction of the resulting tricyclic nitroalkene.
Key words
acylations - intramolecular Henry reaction - nitroalkene - total synthesis.
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