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DOI: 10.1055/s-0028-1083326
Synthesis and Olfactory Evaluation of (4aR*,8aR*)-1,1,8a-Trimethyl-decahydronaphthalen-4a-ol: A cis-Decalol Intersection Structure of (-)-Patchoulol and (5R*,6S*)-1,1,6-Trimethylspiro[4.5]decan-6-ol
Publication History
Publication Date:
26 January 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200903/lookinside/thumbnails/10.1055-s-0028-1083326-1.jpg)
Inadvertently, instead of (-)-patchoulol, the (+)-enantiomer was drawn in Figures [¹] and [²] . As the target compound and all intermediates are racemates, this has no influence on the results, still Figures [¹] and [²] should be replaced by the correct representations below. For the sake of better correlation, the opposite enantiomer has also been delineated for racemic compounds. The authors apologize for this mistake.
Figure 1 Patchouli odorants,
decalin odorants, and the derivation of the cis-decalol intersection
target structure 4
Figure 2 Biflexible superposition
analysis of (-)-patchoulol (1, depicted in
silver) on the patchouli-smelling (5R*,6S*)-1,1,6-trimethylspiro[4.5]decan-6-ol
(3, displayed in gold) with the MOE 2007.09 software
package