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DOI: 10.1055/s-0028-1083305
A Simple and Efficient Preparation of Novel Formaldehyde Derivatives
Publication History
Publication Date:
09 January 2009 (online)
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Abstract
New formaldehyde derivatives were prepared in good yields by a short and versatile route. Several crystal structures of corresponding thioacetic acid esters and thiols were determined. The thioacetates were cleaved under acidic or basic conditions affording the thiols in high yield, thus introducing the new substance classes of N-mercaptomethyl-alkylcarboxamides, N-mercaptomethylsulfonamides, and alkoxymethanethiols.
Key words
N-mercaptomethylcarboxamides - N-mercaptomethylsulfonamides - methoxymethanethiol
- 1
Pfaendler HR. inventors; US Patent 6482818. ; Chem. Abstr. 2000, 132, 137202 - 2
De Lattre J. Chem. Zentralbl. 1912, 83: 1192 - 3
Einhorn A.Ladisch C. Liebigs Ann. Chem. 1905, 343: 264 - 4
Rüfenacht K. Helv. Chim. Acta 1972, 55: 1174 - 5
Kristinsson H.Winkler T. Helv. Chim. Acta 1982, 65: 2606 - 6
Böhme H.Driesen G.Schünemann D. Arch. Pharm. (Weinheim, Ger.) 1961, 294: 344 - 8
White EH.Lim HM. J. Org. Chem. 1987, 52: 2162 - 9
Böhme H.Broese R.Dick A.Eiden F.Schünemann D. Chem. Ber. 1959, 92: 1599
References
CCDC 678213 (4b),
CCDC 694690 (4i), CCDC 678214 (4j), CCDC 694363 (5d),
CCDC 694364 (5g), CCDC 694362 (5h) and CCDC 694365 (5i)
contain the supplementary crystallographic data for this paper.
These data can be obtained free of charge from Cambridge Crystallographic
Data Centre via www.ccdc.cam.ac.uk/
data_request/cif
or from the Cambridge Crystallographic Data Centre, 12 Union Road,
Cambridge CB2 1EZ, UK; fax: +44(1223)336033; e-mail: deposit@ccdc.cam.ac.uk.