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Synthesis 2009(2): 211-216
DOI: 10.1055/s-0028-1083265
DOI: 10.1055/s-0028-1083265
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Facile Synthesis of Thioalkyl- and Di(thioalkyl)-Substituted Bipyridines
Further Information
Received
10 July 2008
Publication Date:
19 December 2008 (online)
Publication History
Publication Date:
19 December 2008 (online)
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Abstract
A convenient three-step synthesis has been developed to prepare a series of homologous 4,4′-di(ω-thioalkyl)-2,2′-bipyridines from 4,4′-dimethylbipyridine. The smallest member of the series, 4,4′-di(thiomethyl)-2,2′-bipyridine, has been synthesized by a slightly different route from 4,4′-bis(trimethylsilylmethyl)-2,2′-bipyridine; the monothiomethyl analogue has been obtained from the corresponding mono(trimethylsilylmethyl)bipyridine. Additionally, the chlororheniumtricarbonyl complex of each of the new thiol-substituted ligands has been prepared.
Key words
bipyridine - thiol - ligands - iodination - alkylation
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