Abstract
N -Methoxy-N -methylamide,
popularly addressed as the Weinreb amide, has surfaced as an amide
with a difference. This amide has served as an excellent acylating
agent for organolithium or organomagnesium reagents and as a robust
equivalent for an aldehyde group. These two aspects have been exploited
exhaustively in various synthetic endeavors. This review presents
the growing synthetic utility of the Weinreb amide not only in academic
circles, but also its popular use on kilogram scale by various pharmaceutical industries
across the globe.
1 Introduction
1.1 Limitations
2 Methods for Preparation
3 Applications
3.1 Use in Heterocyclic Chemistry
3.2 Use in Total Synthesis
3.3 Use in Industry on Kilogram Scale
3.4 Synthetic Equivalents and Building Blocks
4 Miscellaneous
5 Conclusion
Key words
Weinreb amide - Grignard addition - ketones - aldehydes - acylation
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