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Synthesis 2008(22): 3579-3584
DOI: 10.1055/s-0028-1083199
DOI: 10.1055/s-0028-1083199
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Carbon Tetrabromide Promoted Reaction of Amines with Carbon Disulfide: Facile and Efficient Synthesis of Thioureas and Thiuram Disulfides
Further Information
Received
30 June 2008
Publication Date:
23 October 2008 (online)
Publication History
Publication Date:
23 October 2008 (online)
Abstract
A novel carbon tetrabromide promoted one-pot reaction of amines and carbon disulfide under mild conditions has been developed, which provides a straightforward and efficient access to thioureas and thiuram disufides, depending on the nature of the amines employed. The promotion effect is explained as the transient formation of a sulfenyl bromide intermediate from dithiocarbamate and carbon tetrabromide during the reaction.
Key words
carbon tetrabromide - thioureas - thiuram disulfides - sulfenyl bromide
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