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Synlett
DOI: 10.1055/a-2809-7904
Letter

Hydrosilane-Promoted Dehalogenation of Heteroaryl Halides under Air Conditions

Authors

  • Pengfei Yu

    1   School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China (Ringgold ID: RIN91616)

  • Xian-Liang Zhao 

    1   School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China (Ringgold ID: RIN91616)

  • Luyi Chen

    1   School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China (Ringgold ID: RIN91616)

  • Zhihao Zhou

    1   School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China (Ringgold ID: RIN91616)

  • Chang Zhao

    1   School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China (Ringgold ID: RIN91616)
Further Information
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An efficient dehalogenation reaction of α-substituted halogenated heterocycles catalyzed by Pd/C with triethylsilane (TES) was developed. This study explores the catalytic dehalogenation of N-heteroaryl halides using a Pd/C-K 2 CO 3 system, with TES serving as the hydrogen source under air conditions (air and moisture). The reaction conditions are compatible with various functional groups with good to excellent yields.



Publication History

Received: 02 December 2025

Accepted after revision: 09 February 2026

Accepted Manuscript online:
10 February 2026

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