A Formal Aldehydic C–H Borylation

Abstract

Recent research has demonstrated a novel copper-catalyzed method for formal aldehydic C–H borylation utilizing a new sp²–sp³ diboron reagent, LBH₂-Bpin. This approach provides a streamlined route to a wide range of acylboranes, which are valuable intermediates in medicinal chemistry. This Synpact article reviews the traditional synthetic methods of acylboranes and the uniqueness of this aldehydic C–H borylation protocol.

Keywords

Boron - Acylborane - C–H borylation - Hydrogen transfer - Diboron reagent

Publikationsverlauf

Eingereicht: 12. November 2025

Angenommen nach Revision: 27. Januar 2026

Artikel online veröffentlicht:
05. Februar 2026

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