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CC BY 4.0 · Endosc Int Open 2026; 14: a27785386
DOI: 10.1055/a-2778-5386
Original article

EUS-guided gastroenterostomy for benign gastric outlet obstruction: Clinical and technical outcomes from a multicenter cohort study

Authors

  • Anam Rizvi

    1   Division of Gastroenterology and Hepatology, Department of Medicine, New York - Presbyterian Weill Cornell Medical Center, New York, United States

  • Kamal Hassan

    1   Division of Gastroenterology and Hepatology, Department of Medicine, New York - Presbyterian Weill Cornell Medical Center, New York, United States

  • Kate Johnson

    1   Division of Gastroenterology and Hepatology, Department of Medicine, New York - Presbyterian Weill Cornell Medical Center, New York, United States

  • Mouen A. Khashab

    2   Gastroenterology, Johns Hopkins University, Baltimore, United States (Ringgold ID: RIN1466)

  • Farimah Fayyaz

    2   Gastroenterology, Johns Hopkins University, Baltimore, United States (Ringgold ID: RIN1466)

  • Michel Al Mardini

    2   Gastroenterology, Johns Hopkins University, Baltimore, United States (Ringgold ID: RIN1466)

  • Jayanta Samanta 

    3   Department of Gastroenterology and Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

  • Jahnvi Dhar

    3   Department of Gastroenterology and Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

  • Alberto Larghi

    4   Department of Gastroenterology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (Ringgold ID: RIN18654)

  • Carlos Robles-Medranda 

    5   Department of Gastroenterology, Instituto Ecuatoriano de Enfermedades Digestivas, Guayaquil, Ecuador
    6   Endoscopy, Omni Hospital, Guayaquil, Ecuador

  • Juan Alcivar Vasquez

    5   Department of Gastroenterology, Instituto Ecuatoriano de Enfermedades Digestivas, Guayaquil, Ecuador

  • Martha Arevalo

    5   Department of Gastroenterology, Instituto Ecuatoriano de Enfermedades Digestivas, Guayaquil, Ecuador

  • Edoardo Forti

    7   Digestive Endoscopy, Ospedale Niguarda-Ca' Granda, Milan, Italy

  • Irene Cottone

    7   Digestive Endoscopy, Ospedale Niguarda-Ca' Granda, Milan, Italy

  • Jorge Vargas

    8   Department of Gastroenterology and Hepatology, Caja Costarricense de Seguro Social, San Jose, Costa Rica

  • Amrita Sethi

    9   Gastroenterology and Hepatology, Columbia University Medical Center, New York, United States (Ringgold ID: RIN21611)

  • Kavel Visrodia

    10   Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, United States (Ringgold ID: RIN21611)

  • Enad Dawod

    1   Division of Gastroenterology and Hepatology, Department of Medicine, New York - Presbyterian Weill Cornell Medical Center, New York, United States

  • Mark Hanscom

    11   Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, United States (Ringgold ID: RIN12295)

  • Kartik Sampath

    1   Division of Gastroenterology and Hepatology, Department of Medicine, New York - Presbyterian Weill Cornell Medical Center, New York, United States

  • Srihari Mahadev

    11   Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, United States (Ringgold ID: RIN12295)

  • David L. Carr-Locke

    1   Division of Gastroenterology and Hepatology, Department of Medicine, New York - Presbyterian Weill Cornell Medical Center, New York, United States

  • Laith Eyad Baqain 

    12   Department of Medicine, King Hussein Medical Center, Amman, Jordan (Ringgold ID: RIN155133)

  • Reem Z Sharaiha 

    1   Division of Gastroenterology and Hepatology, Department of Medicine, New York - Presbyterian Weill Cornell Medical Center, New York, United States
    • Working Group
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Abstract

Background and study aims

Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is emerging as a minimally invasive alternative for benign gastric outlet obstruction (GOO). This study evaluated its safety, efficacy, and long-term outcomes.

Patients and methods

This international, multicenter retrospective study included 72 patients who underwent EUS-GE for benign GOO across 13 centers. Clinical success was defined as ability to tolerate solid food based on the GOO scoring system. Secondary outcomes included technical success and adverse events (AEs).

Results

Technical success was achieved in 97% of cases. Ability to tolerate solid food improved significantly, from 4% pre-procedure to 90% at 60 days post-procedure (<i>P</i> < 0.00001). Mean time to oral intake was 20.1 hours. AEs were mild,

occurring in 6% intra-procedurally and 10% post-procedurally. Mean follow-up duration was 426.3 days.

Conclusions

EUS-GE demonstrates high technical and clinical success rates with a favorable safety profile for benign GOO, offering a promising alternative to traditional surgical approaches.

Keywords

Endoscopy Upper GI Tract - Endoscopic resection (ESD, EMRc, ...) - Endoscopic ultrasonography - Intervention EUS


Publication History

Received: 22 March 2025

Accepted after revision: 25 August 2025

Article published online:
22 January 2026

© 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Anam Rizvi, Kamal Hassan, Kate Johnson, Mouen A. Khashab, Farimah Fayyaz, Michel Al Mardini, Jayanta Samanta, Jahnvi Dhar, Alberto Larghi, Carlos Robles-Medranda, Juan Alcivar Vasquez, Martha Arevalo, Edoardo Forti, Irene Cottone, Jorge Vargas, Amrita Sethi, Kavel Visrodia, Enad Dawod, Mark Hanscom, Kartik Sampath, Srihari Mahadev, David L. Carr-Locke, Laith Eyad Baqain, Reem Z Sharaiha. EUS-guided gastroenterostomy for benign gastric outlet obstruction: Clinical and technical outcomes from a multicenter cohort study. Endosc Int Open 2026; 14: a27785386.
DOI: 10.1055/a-2778-5386
 

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