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CC BY 4.0 · SynOpen 2026; 10(01): 12-29
DOI: 10.1055/a-2763-7067
DOI: 10.1055/a-2763-7067
graphical review
Unlocking the Potential of Polar Organometallic Reagents in Sustainable Solvents
Authors
This work was carried out under the framework of the National PRIN2022 project MENDELEEV, Ministero dell’Università e della Ricerca (grant no. 2022KMS84P), funded by the European Union – NextGenerationEU, Piano Nazionale di Ripresa e Resilienza (PNRR) Missione 4 C2 I.1.1 (CUP H53D23004580006) and the SOLE-H2 Project, Ministero dell’Ambiente e della Sicurezza Energetica (grant no. RSH2A_000004), funded by the European Union – NextGenerationEU, Piano Nazionale di Ripresa e Resilienza (PNRR) Missione 2 C2 I.3.5 - D.D. 279 05/08/2025. J.G.-A. thanks Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033 (project references PID2020-113473GB-100, RED2022-134287-T, PID2023-148663NB-I00) and ‘Programa de Subvenciones para grupos de investigación de organismos del Principado de Asturias’ [Project Química Inorgánica y Catálisis (QUIMINORCAT); ref. SEK-25-GRU-GIC-24-048].
Abstract
Polar organometallic reagents of the s- and d-block elements are key tools for C–C and C–heteroatom bond formation. Recent advances show that these highly reactive species can operate efficiently in sustainable solvents like water and deep eutectic solvents, under air and at room temperature. Acting as living solvents, these media enable sustainable organometallic transformations and redefine classical reactivity paradigms through the principle of green chemistry.
Key words
organolithium reagents - Grignard reagents - organozinc reagents - organosodium reagents - water - deep eutectic solvents - sustainable solventsPublication History
Received: 24 October 2025
Accepted after revision: 03 December 2025
Accepted Manuscript online:
05 December 2025
Article published online:
20 January 2026
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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