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Synlett
DOI: 10.1055/a-2741-3596
DOI: 10.1055/a-2741-3596
Letter
Iron-catalyzed Transformation of Thioketals to Vinyl Sulfides
Authors
Supported by: Nanjing Agricultural University
Abstract
A novel iron-catalyzed reaction has been developed for the preparation of various vinyl sulfides. This new method enables a range of thioketals to easily access terminal alkenes featuring different alkylthio groups. 28 sulfanes have been efficiently achieved with moderate to good yields. A preparative-scale reaction also proceeds well, demonstrating its further potential in organic synthesis. We further tried to understand its mechanism by DFT calculations. This methodology is significant in sulfur chemistry, giving a new pathway to transform thioketals to vinyl sulfides.
Publication History
Received: 09 October 2025
Accepted after revision: 07 November 2025
Article published online:
26 November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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