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DOI: 10.1055/a-2738-3853
Synthesis of 3,3′-Bis(diphenylphosphine)-2H,2′H-4,4′-bichromenes: Novel Bidentate Diphosphine Ligands
Authors
Supported by: Self-deployment Project Research Program of Haixi Institutes, Chinese Academy of Sciences CXZX-2022-GH03
We acknowledge the generous financial support of National Natural Science Foundation of China (Grant No. 22225107) and the Self-deployment Project Research Program of Haixi Institutes, Chinese Academy of Sciences (CXZX-2022-GH03).
Supported by: National Natural Science Foundation of China 22225107
Abstract
Bidentate diphosphine ligands play a crucial role in metal-catalyzed organic synthesis, yet the structural diversity of existing ligands remains limited. This study reports a novel class of bidentate diphosphine ligands featuring a 2H,2′H-4,4′-bichromene skeleton—a similar framework to classical binaphthalene. These ligands were efficiently synthesized via a Pd-catalyzed C–P cross-coupling reaction. Characterization of their metal complexes revealed adaptable coordination geometries due to the ligand’s inherent flexibility. The utility of this ligand system was demonstrated by its enhanced performance over BINAP in a sterically hindered Suzuki-Miyaura coupling, highlighting its potential in catalysis.
Keywords
Bidentate diphosphine ligands - C–P cross-coupling reaction - Bichromenes - Sterically hindered Suzuki–Miyaura coupling - Ligand’s flexibilityPublication History
Received: 29 September 2025
Accepted after revision: 04 November 2025
Accepted Manuscript online:
04 November 2025
Article published online:
12 January 2026
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