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DOI: 10.1055/a-2733-7605
The interplay between muscle length, range of motion, and exercise selection: a review
Autor*innen
Abstract
Emerging evidence suggests that training at longer muscle lengths may optimize muscle hypertrophy. Of note, there is an interplay between muscle length, range of motion (ROM), and exercise selection. It is difficult to identify whether muscle length per se is the main factor, limiting the ability to draw practical conclusions. Thus, synthesizing these different lines of investigation may help to clarify this topic. Firstly, we offer a comprehensive understanding of the physiological effects arising from muscle contractions in longer, moderate, and shorter muscle lengths. Subsequently, we conducted an unstructured review of long-term studies comparing muscle hypertrophy following: 1) isometric training at different muscle lengths, 2) training with different ROMs, and 3) exercises that train muscles at different muscle lengths and/or with different resistance profiles. Different lines of investigation suggest that muscle length plays a role, as training at longer muscle lengths elicits more favorable muscle growth. Notably, the greater muscle growth often observed after exercises and ROMs that train muscles at longer lengths occurs when there is a relevant external torque in the lengthened position. From a practical perspective, the selection of exercises and ROMs that impose relevant external torque at longer muscle lengths should be considered to optimize muscle growth.
Publikationsverlauf
Eingereicht: 23. Februar 2025
Angenommen: 08. August 2025
Accepted Manuscript online:
28. Oktober 2025
Artikel online veröffentlicht:
17. Februar 2026
© 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Gustavo Ferreira Pedrosa, Mariano Rezende Pereira, Witalo Kassiano. The interplay between muscle length, range of motion, and exercise selection: a review. Sports Med Int Open 2026; 10: a27337605.
DOI: 10.1055/a-2733-7605
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References
- 1 Roberts MD, McCarthy JJ, Hornberger TA. et al. Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions. Physiol Rev 2023; 103: 2679-2757
- 2 Wackerhage H, Schoenfeld BJ, Hamilton DL. et al. Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise. J Appl Physiol 2019; 126: 30-43
- 3 Schoenfeld BJ. Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training. Sports Med 2013; 43: 179-194
- 4 de Freitas MC, Gerosa-Neto J, Zanchi NE. et al. Role of metabolic stress for enhancing muscle adaptations: practical applications. World J Methodol 2017; 7: 46-54
- 5 Flewwelling LD, Hannaian SJ, Cao V. et al. What are the potential mechanisms of fatigue-induced skeletal muscle hypertrophy with low-load resistance exercise training. Am J Physiol Cell Physiol 2025; 328: C1001-C1014
- 6 Pallarés JG, Hernández-Belmonte A, Martínez-Cava A. et al. Effects of range of motion on resistance training adaptations: a systematic review and meta-analysis. Scand J Med Sci Sports 2021; 31: 1866-1881 Epub 2021 Jul 5
- 7 Kassiano W, Nunes JP, Costa B. et al. Does varying resistance exercises promote superior muscle hypertrophy and strength gains? a systematic review. J Strength Cond Res 2022; 36: 1753-1762
- 8 Zabaleta-Korta A, Fernández-Peña E, Torres-Unda J. et al. Regional hypertrophy: the effect of exercises at long and short muscle lengths in recreationally trained women. J Hum Kinet 2023; 87: 259-270
- 9 Oranchuk DJ, Storey AG, Nelson AR. et al. Isometric training and long-term adaptations: effects of muscle length, intensity, and intent: a systematic review. Scand J Med Sci Sports 2019; 29: 484-503
- 10 Wolf M, Androulakis-Korakakis P, Fisher J. et al. Partial vs full range of motion resistance training: a systematic review and meta-analysis. IJSC 2023; 3
- 11 Toigo M, Boutellier U. New fundamental resistance exercise determinants of molecular and cellular muscle adaptations. Eur J Appl Physiol 2006; 97: 643-663
- 12 Williams CD, Salcedo MK, Irving TC. et al. The length-tension curve in muscle depends on lattice spacing. Proc Biol Sci 2013; 280: 20130697
- 13 Zimmermann HB, Macintosh BR, Pupo JD. The relationship between length and active force for submaximal skeletal muscle contractions: a review. Sports Med 2025; 55: 37-47
- 14 MacIntosh BR. Recent developments in understanding the length dependence of contractile response of skeletal muscle. Eur J Appl Physiol 2017; 117: 1059-1071
- 15 Nishikawa K. Titin: a tunable spring in active muscle. Physiology (Bethesda) 2020; 35: 209-217
- 16 Noorkõiv M, Nosaka K, Blazevich AJ. Neuromuscular adaptations associated with knee joint angle-specific force change. Med Sci Sports Exerc 2014; 46: 1525-1537
- 17 Alegre LM, Ferri-Morales A, Rodriguez-Casares R. et al. Effects of isometric training on the knee extensor moment-angle relationship and vastus lateralis muscle architecture. Eur J Appl Physiol 2014; 114: 2437-2446
- 18 Kubo K, Ohgo K, Takeishi R. et al. Effects of isometric training at different knee angles on the muscle-tendon complex in vivo. Scand J Med Sci Sports 2006; 16: 159-167
- 19 Akagi R, Hinks A, Power GA. Differential changes in muscle architecture and neuromuscular fatigability induced by isometric resistance training at short and long muscle-tendon unit lengths. J Appl Physiol (1985) 2020; 129: 173-184
- 20 Schoenfeld BJ, Grgic J. Effects of range of motion on muscle development during resistance training interventions: a systematic review. SAGE Open Med 2020; 8: 2050312120901559
- 21 Kassiano W, Costa B, Nunes JP. et al. Which ROMs lead to Rome? A systematic review of the effects of range of motion on muscle hypertrophy. J Strength Cond Res 2023; 37: 1135-1144
- 22 Helms ER, Fitschen PJ, Aragon AA. et al. Recommendations for natural bodybuilding contest preparation: resistance and cardiovascular training. J Sports Med Phys Fitness 2015; 55: 164-178
- 23 Pedrosa GF, Lima FV, Diniz RCR. et al. Can muscle fatigue in women be influenced by knee extension tasks in different ranges of motion?. Hum Mov 2022; 23: 56-64
- 24 Kassiano W, Costa B, Kunevaliki G. et al. Greater gastrocnemius muscle hypertrophy after partial range of motion training performed at long muscle lengths. J Strength Cond Res 2023; 37: 1746-1753
- 25 Bloomquist K, Langberg H, Karlsen S. et al. Effect of range of motion in heavy load squatting on muscle and tendon adaptations. Eur J Appl Physiol 2013; 113: 2133-2142
- 26 McMahon GE, Morse CI, Burden A. et al. Muscular adaptations and insulin-like growth factor-1 responses to resistance training are stretch-mediated. Muscle Nerve 2014; 49: 108-119
- 27 Pedrosa GF, Lima FV, Schoenfeld BJ. et al. Partial range of motion training elicits favorable improvements in muscular adaptations when carried out at long muscle lengths. Eur J Sport Sci 2022; 22: 1250-1260
- 28 Maeo S, Kobayashi Y, Kinoshita M. et al. Effects of hip extension training performed with full versus partial range of motion at long muscle lengths on muscle hypertrophy and sprint performance. Proceedings of the 28th ECSS Anniversary Congress. 2023: 4-7 Paris, France
- 29 Goto M, Maeda C, Hirayama T. et al. Partial range of motion exercise is effective for facilitating muscle hypertrophy and function through sustained intramuscular hypoxia in young trained men. J Strength Cond Res 2019; 33: 1286-1294
- 30 McMaster DT, Cronin J, McGuigan M. Forms of variable resistance training. Strength Cond J 2009; 31: 52-63
- 31 Hale R, Dorman D, Gonzalez RV. Individual muscle force parameters and fiber operating ranges for elbow flexion-extension and forearm pronation-supination. J Biomech 2011; 44: 650-656
- 32 Maeo S, Meng H, Yuhang W. et al. Greater hamstrings muscle hypertrophy but similar damage protection after training at long versus short muscle lengths. Med Sci Sports Exerc 2020; 53: 825-837
- 33 Rosa A, Vazquez G, Grgic J. et al. Hypertrophic effects of single- versus multi-joint exercise of the limb muscles: a systematic review and meta-analysis. Strength Cond J 2023; 45: 49-57
- 34 Hawkins D. Software for determining lower extremity muscle-tendon kinematics and moment arm lengths during flexion/extension movements. Comput Biol Med 1992; 22: 59-71
- 35 Gordon AM, Huxley AF, Julian FJ. The variation in isometric tension with sarcomere length in vertebrate muscle fibres. J Physiol 1966; 184: 170-192
- 36 Schachar R, Herzog W, Leonard TR. The effects of muscle stretching and shortening on isometric forces on the descending limb of the force-length relationship. J Biomech 2004; 37: 917-926
- 37 Rindom E, Kristensen AM, Overgaard K. et al. Activation of mTORC1 signalling in rat skeletal muscle is independent of the EC-coupling sequence but dependent on tension per se in a dose-response relationship. Acta Physiol (Oxf) 2019; 227: e13336
- 38 Russ DW. Active and passive tension interact to promote Akt signaling with muscle contraction. Med Sci Sports Exerc 2008; 40: 88-95
- 39 van der Pijl R, Strom J, Conijn S. et al. Titin-based mechanosensing modulates muscle hypertrophy. J Cachexia Sarcopenia Muscle 2018; 9: 947-961
- 40 Van Dyke JM, Bain JL, Riley DA. Stretch-activated signaling is modulated by stretch magnitude and contraction. Muscle Nerve 2014; 49: 98-107
- 41 Mizuno M, Tokizawa K, Muraoka I. Changes in perfusion related to muscle length affect the pressor response to isometric muscle contraction. Adv Exp Med Biol 2010; 662: 371-377
- 42 Kooistra RD, de Ruiter CJ, de Haan A. Muscle activation and blood flow do not explain the muscle length-dependent variation in quadriceps isometric endurance. J Appl Physiol 2005; 98: 810-816
- 43 Kooistra RD, Blaauboer ME, Born JR. et al. Knee extensor muscle oxygen consumption in relation to muscle activation. Eur J Appl Physiol 2006; 98: 535-545
- 44 Dankel SJ, Mattocks KT, Jessee MB. et al. Do metabolites that are produced during resistance exercise enhance muscle hypertrophy?. Eur J Appl Physiol 2017; 117: 2125-2135
- 45 Loenneke JP, Fahs CA, Rossow LM. et al. The anabolic benefits of venous blood flow restriction training may be induced by muscle cell swelling. Med Hypotheses 2012; 78: 151-154
- 46 Loenneke JP, Wilson JM, Marín PJ. et al. Low intensity blood flow restriction training: a meta-analysis. Eur J Appl Physiol 2012; 112: 1849-1859
- 47 Fouré A, Ogier AC, Guye M. et al. Muscle alterations induced by electrostimulation are lower at short quadriceps femoris length. Eur J Appl Physiol 2020; 120: 325-335
- 48 Hirono T, Ikezoe T, Taniguchi M. et al. Relationship between muscle swelling and hypertrophy induced by resistance training. J Strength Cond Res 2022; 36: 359-364
- 49 Weir JP, Ayers KM, Lacefield JF. et al. Mechanomyographic and electromyographic responses during fatigue in humans: influence of muscle length. Eur J Appl Physiol 2000; 81: 352-359
- 50 Pope ZK, Hester GM, Benik FM. et al. Action potential amplitude as a noninvasive indicator of motor unit-specific hypertrophy. J Neurophysiol 2016; 115: 2608-2614
- 51 Nakao S, Ikezoe T, Taniguchi M. et al. Effects of low-intensity torque-matched isometric training at long and short muscle lengths of the hamstrings on muscle strength and hypertrophy: a randomized controlled study. J Strength Cond Res 2023; 37: 1978-1984
- 52 McMahon G, Onambele-Pearson G. Joint angle-specific neuromuscular time course of recovery after isometric resistance exercise at shorter and longer muscle lengths. J Appl Physiol 2024; 136: 889-900
- 53 McMahon GE, Morse CI, Burden A. et al. Impact of range of motion during ecologically valid resistance training protocols on muscle size, subcutaneous fat, and strength. J Strength Cond Res 2014; 28: 245-255
- 54 Kubo K, Ikebukuro T, Yata H. Effects of squat training with different depths on lower limb muscle volumes. Eur J Appl Physiol 2019; 119: 1933-1942
- 55 Valamatos MJ, Tavares F, Santos RM. et al. Influence of full range of motion vs. equalized partial range of motion training on muscle architecture and mechanical properties. Eur J Appl Physiol 2018; 118: 1969-1983
- 56 Baltzopoulos V, Brodie DA. Isokinetic dynamometry. applications and limitations. Sports Med 1989; 8: 101-116
- 57 Folland J, Morris B. Variable-cam resistance training machines: do they match the angle-torque relationship in humans?. J Sports Sci 2008; 26: 163-169
- 58 Pinto RS, Gomes N, Radaelli R. et al. Effect of range of motion on muscle strength and thickness. J Strength Cond Res 2012; 26: 2140-2145
- 59 Pedrosa GF, Simões MG, Figueiredo MOC. et al. Training in the initial range of motion promotes greater muscle adaptations than at final in the arm curl. Sports (Basel) 2023; 11: 39
- 60 Werkhausen A, Solberg CE, Paulsen G. et al. Adaptations to explosive resistance training with partial range of motion are not inferior to full range of motion. Scand J Med Sci Sports 2021; 31: 1026-1035
- 61 Douglas J, Pearson S, Ross A. et al. Chronic adaptations to eccentric training: a systematic review. Sports Med 2017; 47: 917-941
- 62 Dankel SJ, Jessee MB, Mattocks KT. et al. Training to fatigue: the answer for standardization when assessing muscle hypertrophy. Sports Med 2017; 47: 1021-1027
- 63 Wolf M, Androulakis Korakakis P, Piñero A. et al. Lengthened partial repetitions elicit similar muscular adaptations as full range of motion repetitions during resistance training in trained individuals. PeerJ 2025; 13: e18904
- 64 Sato S, Yoshida R, Ryosuke K. et al. Elbow joint angles in elbow flexor unilateral resistance exercise training determine its effects on muscle strength and thickness of trained and non-trained arms. Front Physiol 2021; 16: 734509
- 65 Kinoshita M, Maeo S, Kobayashi Y. et al. Triceps surae muscle hypertrophy is greater after standing versus seated calf-raise training. Front Physiol 2023; 13: 1272106
- 66 Burke R, Piñero A, Mohan AE. et al. Exercise selection differentially influences lower body regional muscle development. J Sci Sport Exerc 2024; Epub ahead of print
- 67 Maeo S, Balshaw TG, Nin DZ. et al. Hamstrings hypertrophy is specific to the training exercise: Nordic hamstring versus lengthened state eccentric training. Med Sci Sports Exerc 2024; 56: 1893-1905
- 68 Kellis E, Blazevich AJ. Hamstrings force-length relationships and their implications for angle-specific joint torques: a narrative review. BMC Sports Sci Med Rehabil 2022; 14: 166
- 69 Larsen S, Sandvik Kristiansen B, Swinton PA. et al. The effects of hip flexion angle on quadriceps femoris muscle hypertrophy in the leg extension exercise. J Sports Sci 2025; 43: 210-221
- 70 Maeo S, Wu Y, Huang M. et al. Triceps brachii hypertrophy is substantially greater after elbow extension training performed in the overhead versus neutral arm position. Eur J Sport Sci 2023; 23: 1240-1250
- 71 Stasinaki A-N, Zaras N, Methenitis S. et al. Triceps brachii muscle strength and architectural adaptations with resistance training exercises at short or long fascicle length. J Funct Morphol Kinesiol 2018; 3: 28
- 72 Nunes JP, Jacinto JL, Ribeiro AS. et al. Placing greater torque at shorter or longer muscle lengths? Effects of cable vs. barbell preacher curl training on muscular strength and hypertrophy in young adults. Int J Environ Res Public Health 2020; 17: 5859
- 73 Larsen S, Wolf M, Schoenfeld BJ. et al. Dumbbell versus cable lateral raises for lateral deltoid hypertrophy: an experimental study. SportRxiv 2024; Preprint
- 74 Hinks A, Franchi MV, Power GA. The influence of longitudinal muscle fascicle growth on mechanical function. J Appl Physiol (1985) 2022; 133: 87-103
- 75 Pedrosa GF, Simões MG, Rezende Pereira M. et al. From full to partials: investigating the impact of range of motion training on maximum isometric action, and muscle hypertrophy in young women. J Sports Sci 2025; 43: 1440-1451
- 76 Hudson AL, Gandevia SC, Butler JE. A principle of neuromechanical matching for motor unit recruitment in human movement. Exerc Sport Sci Rev 2019; 47: 157-168
- 77 Kassiano W, Costa B, Kunevaliki G. et al. Muscle hypertrophy and strength adaptations to systematically varying resistance exercises. Res Q Exerc Sport 2025; 96: 371-381
