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CC BY 4.0 · Surg J (N Y) 2025; 11: a27195405
DOI: 10.1055/a-2719-5405
Case Report

Undifferentiated Embryonal Sarcoma of the Liver: Report of Two Cases and Literature Review

Authors

  • Souad Ghattas 

    1   Department of General Surgery, Balamand University, Beirut, Lebanon

  • Jad Al Bitar 

    1   Department of General Surgery, Balamand University, Beirut, Lebanon

  • Hani Maalouf

    1   Department of General Surgery, Balamand University, Beirut, Lebanon

  • Ribal Aby Hadeer

    1   Department of General Surgery, Balamand University, Beirut, Lebanon

  • Rawan Abdallah 

    1   Department of General Surgery, Balamand University, Beirut, Lebanon

  • Antoine El Asmar 

    2   Department of General Surgery, Saint Georges Hospital University Medical Center, Beirut, Lebanon

  • Wissam Dib

    2   Department of General Surgery, Saint Georges Hospital University Medical Center, Beirut, Lebanon

  • Hind Rahban

    3   Head of Laboratory Department, Lebanese American University Medical Center, Beirut, Lebanon

  • Ziad El Rassi

    4   Head of General Surgery Department, Saint Georges Hospital University Medical Center, Beirut, Lebanon
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Abstract

Undifferentiated embryonal sarcoma of the liver is a rare tumor of mesenchymal origin, representing about 9 to 15% of pediatric hepatic tumors. Usually diagnosed in children between 6 and 10 years of age, it has no specific clinical or laboratory features. Its diagnosis is usually delayed due to nonspecific symptoms, leading to poorer outcomes. Early diagnosis is key to increasing the chances of long-term survival. We report two cases of undifferentiated embryonal sarcoma in children presenting with hemoperitoneum from spontaneous rupture of the tumor.

Keywords

UESL - liver tumor - sarcoma - hepatectomy

Ethical Approval

Case report approved for publishing by the Ethical Committee at Saint George hospital University Medical Center, and Head of General Surgery Division.




Publication History

Received: 29 July 2025

Accepted: 09 October 2025

Article published online:
06 November 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Souad Ghattas, Jad Al Bitar, Hani Maalouf, Ribal Aby Hadeer, Rawan Abdallah, Antoine El Asmar, Wissam Dib, Hind Rahban, Ziad El Rassi. Undifferentiated Embryonal Sarcoma of the Liver: Report of Two Cases and Literature Review. Surg J (N Y) 2025; 11: a27195405.
DOI: 10.1055/a-2719-5405
 

  • References

  • 1 Mathias MD, Ambati SR, Chou AJ. et al. A single-center experience with undifferentiated embryonal sarcoma of the liver. Pediatr Blood Cancer 2016; 63 (12) 2246-2248
    Search in Google Scholar
  • 2 Guérin F, Martelli H, Rogers T. et al. Outcome of patients with undifferentiated embryonal sarcoma of the liver treated according to European soft tissue sarcoma protocols. Pediatr Blood Cancer 2023; 70 (07) e30374
    Search in Google Scholar
  • 3 Wu Z, Wei Y, Cai Z, Zhou Y. Long-term survival outcomes of undifferentiated embryonal sarcoma of the liver: a pooled analysis of 308 patients. ANZ J Surg 2020; 90 (09) 1615-1620
    Search in Google Scholar
  • 4 Kallam A, Krishnamurthy J, Kozel J, Shonka N. Undifferentiated embryonal sarcoma of liver. Rare Tumors 2015; 7 (04) 6009
    Search in Google Scholar
  • 5 Techavichit P, Masand PM, Himes RW. et al. Undifferentiated embryonal sarcoma of the liver (UESL): a single-center experience and review of the literature. J Pediatr Hematol Oncol 2016; 38 (04) 261-268
    Search in Google Scholar
  • 6 Putra J, Ornvold K. Undifferentiated embryonal sarcoma of the liver: a concise review. Arch Pathol Lab Med 2015; 139 (02) 269-273
    Search in Google Scholar
  • 7 Wei ZG, Tang LF, Chen ZM, Tang HF, Li MJ. Childhood undifferentiated embryonal liver sarcoma: clinical features and immunohistochemistry analysis. J Pediatr Surg 2008; 43 (10) 1912-1919
    Search in Google Scholar
  • 8 Ismail H, Dembowska-Bagińska B, Broniszczak D. et al. Treatment of undifferentiated embryonal sarcoma of the liver in children–single center experience. J Pediatr Surg 2013; 48 (11) 2202-2206
    Search in Google Scholar
  • 9 Lauwers GY, Grant LD, Donnelly WH. et al. Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. Am J Surg Pathol 1997; 21 (10) 1248-1254
    Search in Google Scholar