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CC BY 4.0 · J Neurol Surg Rep 2025; 86(02): e92-e97
DOI: 10.1055/a-2576-7559
Case Report

Recurrent Glioblastoma Resection with Microvascular Free Flap Reconstruction and Associated GammaTile Implantation: A Personalized Approach with Oncologic and Reconstructive Integration

Russel T. Wagner
1   Intent Medical Group, Endeavor Health Advanced Neurosciences Institute, Northwest Community Hospital, Arlington Heights, Illinois, United States
,
Jacopo Berardinelli
2   Division of Neurosurgery, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Napoli, Campania, Italy
,
Amin B. Kassam
1   Intent Medical Group, Endeavor Health Advanced Neurosciences Institute, Northwest Community Hospital, Arlington Heights, Illinois, United States
,
Julian E. Bailes
3   Endeavor Health Neurosciences, NorthShore Neurological Institute, Evanston, Illinois, United States
,
Melanie B. Fukui
1   Intent Medical Group, Endeavor Health Advanced Neurosciences Institute, Northwest Community Hospital, Arlington Heights, Illinois, United States
,
George C. Bobustuc
1   Intent Medical Group, Endeavor Health Advanced Neurosciences Institute, Northwest Community Hospital, Arlington Heights, Illinois, United States
,
Sammy Khalili
1   Intent Medical Group, Endeavor Health Advanced Neurosciences Institute, Northwest Community Hospital, Arlington Heights, Illinois, United States
,
Neil S. Mundi
1   Intent Medical Group, Endeavor Health Advanced Neurosciences Institute, Northwest Community Hospital, Arlington Heights, Illinois, United States
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Abstract

Background

Glioblastoma multiforme (GBM), despite aggressive multimodal treatment comprising surgery followed by chemoradiation, is almost uniformly associated with inevitable recurrence and poor outcomes. In this clinical context, local radiation therapy—an emerging approach—has gained considerable attention over time for its potential to address the limitations of traditional treatment options for GBM. Multiple surgeries and adjuvant chemoradiation therapy can negatively impact the integrity of the scalp soft tissues and can compromise the ability to achieve primary closure over the surgical site. In these circumstances, complex reconstruction with free tissue transfer may be necessary.

Methods

We report the case of a 37-year-old female patient with recurrent GBM and associated wound healing complications who underwent single-stage GammaTile surgically targeted radiation therapy combined with microvascular free flap scalp reconstruction.

Results

Immediate free flap reconstruction over the site of GammaTile implantation did not result in any wound healing complications and did not compromise the viability of the transplanted tissue. This approach also provided immediate and localized radiation, possibly enhancing patient progression-free survival while reducing the likelihood of radiation-induced adverse effects.

Conclusion

We report the first case of GammaTile implantation with immediate reconstruction of the overlaying soft tissue defect with a free flap. Despite the immediate local radiation produced by the tiles abutting the deep surface of the free flap, there were no complications noted in the vascularity of the transplanted tissue. This finding provides preliminary evidence supporting the safety of using free tissue transfer alongside GammaTile implantation for complex reconstruction.

Keywords

Glioblastoma multiforme - GammaTile therapy - microvascular free flap - Multidisciplinary management - recurrent brain tumor - scalp reconstruction - brachytherapy - oncologic integration - tissue viability


Publication History

Received: 09 January 2025

Accepted: 19 March 2025

Accepted Manuscript online:
08 April 2025

Article published online:
25 April 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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