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Synthesis
DOI: 10.1055/a-2502-7759
short review

Stereoselective Construction of Glycosides Enabled by Glycosyl/Glycal Metal Species

Xiaomei Wu
1   Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, China (Ringgold ID: RIN12635)
,
Xin Yan
1   Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, China (Ringgold ID: RIN12635)
,
Deyun Qian 
1   Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, China (Ringgold ID: RIN12635)
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Glycosyl/glycal metal functionalization has emerged as an efficient protocol for the construction of glycosides. Benefitting from the rapid development of organometallic chemistry and transition-metal catalyzed cross-coupling reaction, glycosyl-metal mediated glycosylation has significantly expanded the space for glycoside synthesis recently. In this short review, we underscore the representative progress in this area, categorizing the advancements by the type of glycosyl/glycal metal species. The reaction mechanism, stereochemical control, synthetic utility, and unmet challenges are also discussed.



Publication History

Received: 22 November 2024

Accepted after revision: 15 December 2024

Accepted Manuscript online:
15 December 2024

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