Association between ACE (I/D) polymorphism and physical performance
                    in Brazilian handballers

Valmir Oliveira Silvino; Sandro Soares Almeida; Helen Matias Apaza; Rayane Carvalho de Moura; Crislane de Moura Costa; Cirley Pinheiro Ferreira; George Sales Beleense; Sérgio Luís Galan Ribeiro; Marcos Antonio Pereira dos Santos

doi:10.1055/a-2443-9765

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2025; 46(04): 296-301
DOI: 10.1055/a-2443-9765

Genetics & Molecular Biology

Association between ACE (I/D) polymorphism and physical performance in Brazilian handballers

Valmir Oliveira Silvino

¹Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, Brazil (Ringgold ID: RIN67823)

²Rede Nordeste de Biotecnologia (RENORBIO) post-graduation program, Teresina, Brazil (Ringgold ID: RIN28105)

,

Sandro Soares Almeida

³Hospital Israelita Albert Einstein, São Paulo, Brazil (Ringgold ID: RIN67823)

⁴Faculdade Anhanguera de Guarulhos, Guarulhos, São Paulo, Brazil (Ringgold ID: RIN67823)

⁵Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo Unifesp, São Paulo, Brazil (Ringgold ID: RIN67823)

,

Helen Matias Apaza

⁵Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo Unifesp, São Paulo, Brazil (Ringgold ID: RIN67823)

,

Rayane Carvalho de Moura

¹Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, Brazil (Ringgold ID: RIN67823)

,

Crislane de Moura Costa

¹Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, Brazil (Ringgold ID: RIN67823)

,

Cirley Pinheiro Ferreira

¹Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, Brazil (Ringgold ID: RIN67823)

²Rede Nordeste de Biotecnologia (RENORBIO) post-graduation program, Teresina, Brazil (Ringgold ID: RIN28105)

,

George Sales Beleense

¹Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, Brazil (Ringgold ID: RIN67823)

,

Sérgio Luís Galan Ribeiro

¹Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, Brazil (Ringgold ID: RIN67823)

,

Marcos Antonio Pereira dos Santos

¹Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui, Teresina, Brazil (Ringgold ID: RIN67823)

²Rede Nordeste de Biotecnologia (RENORBIO) post-graduation program, Teresina, Brazil (Ringgold ID: RIN28105)

› Institutsangaben

Abstract

This study investigated the association between the ACE (I/D) polymorphism and strength phenotypes in Brazilian male handball players, considering their playing position. A total of 105 male junior handball players and 92 controls were evaluated. The ACE I/D polymorphism was genotyped by conventional PCR followed by electrophoresis in agarose gel. All participants were anthropometrically evaluated and performed the standing long jump (SLJ) and medicine ball throw (MBT) tests. Athletes presented superior performance in the SLJ and MBT tests compared to the control group in all playing positions (p<0.01). No significant differences were observed in genotype or allele frequencies when comparing athletes and controls or among playing positions. However, a significant difference was observed when comparing all athletes to controls using the over-dominant model (II+DD vs. ID; p=0.035). Additionally, ID athletes had better performance in the MBT than DD players (p=0.04), athletes with II+ID and II+DD genotypes exhibited superior performance in the SLJ test (p<0.04), and ID athletes demonstrated increased height compared to II+DD counterparts (p=0.01). In conclusion, our data showed a potential association between ACE (I/D) polymorphism and overall athletic predisposition in handball players, with no association with playing position.

Keywords

angiotensin-converting enzyme - genotype - gene - strength - sports - handball

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Referenzen

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