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DOI: 10.1055/a-2443-1745
Novel and efficient process for the synthesis of 1,3,4 Oxadiazole containing MBX-4132
A novel and efficient approach to the synthesis of MBX-4132 has been reported. Having 1,3,4-oxadiazole containing compound that inhibits trans translation process by binding to the bacterial ribosome and act as an antimicrobial agent. It involved the reaction of 5-(4-fluorophenyl)-1,3,4-oxadiazol-2-amine, with diphenyl carbonate to yield the corresponding carbamates, which in-situ reacted with 1,2,3,4-tetrahydroisoquinoline to produce MBX-4132 with a comparatively higher yield (65%). The above process involves mild reaction conditions and uses non-toxic, non-hazardous and cheaper reagents such as diphenyl carbonate as carbonyl source thereby making the process economical and environment friendly.
Publication History
Received: 15 May 2024
Accepted after revision: 16 October 2024
Accepted Manuscript online:
04 December 2024
© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
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