Pulmonary Metastasectomy after Immune Checkpoint Inhibitors in Renal Cell Carcinoma

Abstract

The management of oligometastatic renal cell carcinoma with pulmonary metastases is controversial and occasionally requires multimodality management, including salvage pulmonary metastasectomy after immune checkpoint inhibitors (ICIs). However, limited data are available on these patients. We describe a case series of three consecutive patients who underwent salvage pulmonary metastasectomy after ICIs for oligometastatic renal cell carcinoma and discussed the important characteristics of these patients. After salvage pulmonary metastasectomy, none of the patients had recurrent pulmonary metastases, although one of them developed a brain metastasis postoperatively. Our case series suggests that salvage pulmonary metastasectomy after ICIs may control pulmonary metastases in carefully selected patients with oligometastatic renal cell carcinoma, although the management of extrapulmonary metastases may be required after salvage pulmonary metastasectomy.

Keywords

immune checkpoint inhibitors - metastatic tumor - surgery

Ethical Approval Statement

All the in the study procedures were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all the patients for publication.

Publication History

Received: 01 July 2024

Accepted: 06 September 2024

Accepted Manuscript online:
09 September 2024

Article published online:
10 October 2024

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