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Am J Perinatol
DOI: 10.1055/a-2407-0946
Review Article

A Review of Third-Trimester Complications in Pregnancies Complicated by Diabetes Mellitus

Shaun R. Welsey
1   Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Rochester Medical Center, Rochester, New York
,
Jessica Day
2   Department of Obstetrics and Gynecology, Inova Fairfax, Fairfax, Virginia
,
Scott Sullivan
2   Department of Obstetrics and Gynecology, Inova Fairfax, Fairfax, Virginia
,
Sarah D. Crimmins 
1   Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Rochester Medical Center, Rochester, New York
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Abstract

Pregnancies affected by both pregestational and gestational diabetes mellitus carry an increased risk of adverse maternal and neonatal outcomes. While the risks associated with diabetes in pregnancy have been well documented and span across all trimesters, maternal and neonatal morbidity have been associated with select third-trimester complications. Further, modifiable risk factors have been identified that can help improve pregnancy outcomes. This review aims to examine the relationship between select third-trimester complications (large for gestational age, intrauterine fetal demise, hypertensive disorders of pregnancy, preterm birth, perineal lacerations, shoulder dystocia, and cesarean delivery) and the aforementioned modifiable risk factors, specifically glycemic control, blood pressure control, and gestational weight gain. It also highlights how early optimization of these modifiable risk factors can reduce adverse maternal, fetal, and neonatal outcomes.

Key Points

  • Diabetes mellitus in pregnancy increases the risk of third-trimester complications.

  • Modifiable risk factors exist for these complications.

  • Optimizing these modifiable risk factors improves maternal and neonatal outcomes.

Keywords

diabetes in pregnancy - diabetes mellitus - hypertension - gestational weight gain - glycemic control - fetal demise in utero - cesarean section - perineal lacerations


Publication History

Received: 25 April 2024

Accepted: 27 August 2024

Article published online:
30 September 2024

© 2024. Thieme. All rights reserved.

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