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CC BY-NC-ND 4.0 · J Am Acad Audiol
DOI: 10.1055/a-2370-2695
Research Article

In Vitro Fertilization and Hearing Impairment in Twins

Mingming Guo
1   Department of Otolaryngology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN117980)
,
Hanyao Liu
1   Department of Otolaryngology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN117980)
,
Seni Liao
2   Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases;Guangdong Provincial Clinical Reserach Center for Obstetrics and Gynecology;Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN117980)
,
Jinxia Huang
3   Department of Clinical Medicine, Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN26468)
,
Ziruo Tan
3   Department of Clinical Medicine, Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN26468)
,
Peixi Mo
3   Department of Clinical Medicine, Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN26468)
,
Shunlin Ouyang
1   Department of Otolaryngology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN117980)
,
Huasong Zhang 
1   Department of Otolaryngology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN117980)
,
Yanhong Chen
2   Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases;Guangdong Provincial Clinical Reserach Center for Obstetrics and Gynecology;Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (Ringgold ID: RIN117980)
› Author AffiliationsSupported by: Medical and Health Science and Technology Plan of Longgang Shenzhen LGKCYLWS2022019
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Objective: This study investigates the potential correlation between in vitro fertilization (IVF) and hearing impairment in twins compared to naturally conceived twins. Method: Analyzing data from 2416 twin infants born between 2019 and 2021. Analyze the pregnancy conditions and complications of mothers, the birth conditions of newborns, perinatal diseases, initial hearing screening results, and subsequent follow-up conditions. Results: Our findings reveal that the incidence of hearing impairment in IVF-conceived twins is comparable to that in naturally conceived twins. Significant differences in low birth weight, preterm birth, respiratory distress syndrome, and hyperbilirubinemia were observed between infants who passed and referred the hearing screening (P ＜ 0.05). The IVF group exhibited a lower incidence of low birth weight (P < 0.05) and older maternal age (P < 0.05), while showing higher rates of placental abnormalities and placental abruption (P < 0.05). Notably, these distinctions did not translate into a significant impact on hearing impairment. Regardless of the method of conception, the following key factors contributing to hearing impairment in twins were identified: low birth weight, preterm birth, respiratory distress syndrome, and hyperbilirubinemia. Conclusion: IVF technology does not exert specific effects on hearing impairment in twins, with perinatal complications being the primary influencing factors.



Publication History

Received: 14 January 2024

Accepted after revision: 15 July 2024

Accepted Manuscript online:
22 July 2024

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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