A New Synthesis of UK-2A Acid Facilitated by a Triple Chloro-Pummerer Activation

Abstract

A new method for the preparation of 3-hydroxy-4-methoxypicolinic acid, the acid moiety of the fungicidally active natural product UK-2A is reported. In contrast to the two previously reported routes to UK-2A acid, which start from 3-hydroxypyridine and furfural, this novel synthesis applies maltol as inexpensive starting material and proceeds via a unique modification of the Pummerer reaction.

Key words

UK-2A - fungicide - antifungal - synthesis - Pummerer reaction

Publication History

Received: 25 April 2024

Accepted after revision: 27 May 2024

Accepted Manuscript online:
27 May 2024

Article published online:
19 June 2024

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