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DOI: 10.1055/a-2331-6399
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Isotopic Labeling

Multicomponent Reactions: A Promising Approach to Isotope Labeling

Siyu Xiao
a   University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
,
Antonio Conte
b   Institute of Molecular and Translational Medicine, Faculty of ­Medicine and Dentistry and Czech Advanced Technology and ­Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic
,
Bart T. Cornelissen
a   University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
,
Alexander Domling∗
b   Institute of Molecular and Translational Medicine, Faculty of ­Medicine and Dentistry and Czech Advanced Technology and ­Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic
,
Philip H. Elsinga∗
a   University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
› Author AffiliationsThis research has been supported (to AD) through the ERA Chair grant ACCELERATOR (101087318), the ERC Advanced grant AMADEUS (101098001), and the VIDEC grant (872195). This study was supported (AD) by the National Institute for Cancer Research—Programme EXCELES (ID Project No. LX22NPO5102), funded by the Cancer Research Czech Republic, and the Dutch Cancer Society (KWF Kankerbestrijding, KWF) grant (14712).
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Abstract

Isotopic labeling is an attractive modality that has been widely used in many aspects of chemistry, the life sciences, and medical research; especially deuterated drugs and radioactive molecules have been used in the diagnosis and treatment of cancer and neurodegenerative diseases. The widespread application and rapid development of isotopically labeled molecules has led to an increased demand for new isotopic labeling chemical methods to synthesize highly specific molecules bearing defined nuclides. Multicomponent reactions (MCRs) are modular build-up approaches for the rapid generation of complex molecules often containing biologically relevant scaffold structures. There is great potential to use MCRs to construct isotopically labeled molecules because assembly speed and reaction diversity are key advantages of MCR. In this review, we provide an overview of the recent literature on this topic that can provide insight into the application of MCRs in the field of isotopic labeling.

Key words

MCR - multicomponent reaction - Ugi - Passerini - isotope - PET - deuterium - isocyanide


Publication History

Received: 11 February 2024

Accepted after revision: 22 May 2024

Accepted Manuscript online:
22 May 2024

Article published online:
18 September 2024

© 2024. The Authors. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

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