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DOI: 10.1055/a-2316-4772
Diagnostic Value of Stimulated Urine Luteinizing Hormone After Triptorelin Stimulation Test in Girls with Central Precocious Puberty
Funding Information This project was supported by the Top Talent Support Program for young and middle-aged people in the second term of Wuxi Health Committee (BJ2023054), the Top Talent Support Program for young and middle-aged people of the Wuxi Health Committee (HB2020038), the Maternal and Child Health Research Project of Jiangsu in China ( F202117), the Wuxi Translational Medicine Research Institute (LCYJ202342), the Maternal and Child Health Research Project of Wuxi in China (FYKY201804), and the Excellent Program for Overseas Students of Wuxi City in 2018 (23), China.![](https://www.thieme-connect.de/media/eced/202407/lookinside/thumbnails/01-2024-0027-endo_10.1055-a-2316-4772-1.jpg)
Abstract
Objective To investigate the diagnostic value of urine luteinizing hormone (ULH) after the triptorelin stimulation test detected by immunochemiluminometric assay (ICMA) in girls with central precocious puberty (CPP).
Methods The girls with precocious puberty were included. The triptorelin stimulation test at 8:30 a.m. was performed. Two consecutive 12-hour urine samples were collected after the test, defined as the first 12-hour and second 12-hour urine, respectively. ICMA measured ULH. Urine creatinine (Cr) concentration was measured. CPP and peripheral precocious puberty (PPP) were diagnosed by the same pediatric endocrinologist based on clinical symptoms, signs, and progression of clinical development.
Results A total of 97 cases (CPP n=69; PPP n=28) were included, with 12 cases not meeting the receiver operating characteristic analysis criteria. The first and second 12-hour ULH/Cr in the CPP group were higher than those in the PPP group. When the first 12-hour ULH/Cr was≥287.252 IU/mol, the sensitivity and specificity for diagnosing CPP were 87.3% and 90.9%, respectively. When the second 12-hour ULH/Cr was≥152.769 IU/mol, the sensitivity and specificity for diagnosing CPP were 92.1% and 90.9%, respectively. The area under the curve of the first and second 12-hour ULH/Cr were 0.933 and 0.954, respectively.
Conclusion The ULH detection method after the triptorelin stimulation test has clinical significance for diagnosing CPP in girls. When blood sampling compliance in girls with precocious puberty is poor, the first 12-hour ULH/Cr≥288 IU/mol (or second 12-hour≥153 IU/mol) after the triptorelin stimulation test can serve as a laboratory indicator for diagnosis of CPP.
Keywords
urine gonadotropin - girls - central precocious puberty - diagnosis - hypothalamic-pituitary-gonadal axis‡ These authors share first authorship.
Publication History
Received: 25 January 2024
Received: 21 March 2024
Accepted Manuscript online:
29 April 2024
Article published online:
16 July 2024
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