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Synlett 2024; 35(18): 2138-2142
DOI: 10.1055/a-2293-3243
DOI: 10.1055/a-2293-3243
letter
Rapid Cyclic Acetal and Cyclic Ketal Synthesis Assisted by a Rotary Evaporator
This work was supported by the Research Development Fund (RDF-20-02-30), PGRS2112027, and FOSA2212021) from Xi’an Jiaotong-Liverpool University.
Abstract
Herein, we present a rapid and efficient method for synthesizing cyclic acetals and ketals utilizing a rotary evaporator. Unlike the conventional Dean–Stark dehydration process, which typically demands extended reaction times and copious amounts of organic solvents, our approach affords the synthesis of cyclic acetals and ketals with varying ring sizes in 30 min while using minimal quantities of dimethyl sulfoxide as the solvent. This innovative protocol features high yields, fast reactions, easy operation, and broad substrate applicability.
Key words
cyclic acetal - cyclic ketal - dehydrative reaction - rotary evaporator - rotavap-assisted synthesisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2293-3243.
- Supporting Information
Publikationsverlauf
Eingereicht: 01. März 2024
Angenommen nach Revision: 22. März 2024
Accepted Manuscript online:
22. März 2024
Artikel online veröffentlicht:
08. April 2024
© 2024. Thieme. All rights reserved
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