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Drug Res (Stuttg) 2024; 74(04): 180-186
DOI: 10.1055/a-2266-2522
Original Article

Sweeteners in Orodispersible Films: How Much is too Much?

Ognjenka Rahić 
1   University of Sarajevo – Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina
,
Sabina Behrem
1   University of Sarajevo – Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina
,
Amina Tucak-Smajić
1   University of Sarajevo – Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina
,
Jasmina Hadžiabdić
1   University of Sarajevo – Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina
,
Belma Imamović
2   University of Sarajevo – Faculty of Pharmacy, Department of Drug Analysis, Sarajevo, Bosnia and Herzegovina
,
Lamija Hindija
1   University of Sarajevo – Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina
,
Merima Šahinović
1   University of Sarajevo – Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina
,
Edina Vranić
1   University of Sarajevo – Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina
› Author Affiliations Funding Information Ministry of Science, Higher Education and Youth of Canton Sarajevo — 27–02–35–37082–22/23 This research was funded by the Ministry of Science, Higher Education and Youth of Canton Sarajevo, grant number 27–02–35–37082–22/23, date: 14 September 2023.
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Abstract

Four natural sweeteners (sucrose, xylitol, fructose, and isomalt) were selected to examine the influence of their qualities and amounts on the characteristics of orodispersible films. Sodium carboxymethylcellulose (2% w/w) was utilized as the film-forming polymer and 1% w/w glycerol as a plasticizer. Films were produced through the solvent casting method, rendering them suitable for convenient application in community or hospital pharmacy settings. The physicochemical and optical properties of the films were analyzed, and Fourier-transform infrared analysis was carried out. All films exhibited acceptable disintegration time, uniformity of mass, thickness, and optical characteristics, with significant dependence (p<0.05) on both sweetener type and quantity. Disintegration time varied based on the employed method, as well as the characteristics and amount of sweetener. Additionally, all films maintained pH values within the oral cavity range, suggesting no potential irritancy upon administration. Fourier-transform infrared analysis confirmed the formation of the film and demonstrated compatibility between its components.

Keywords

natural sweeteners - orodispersible films - sodium carboxymethylcellulose - characteristics


Publication History

Received: 08 January 2024

Accepted: 30 January 2024

Article published online:
20 March 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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