Klin Monbl Augenheilkd 2024; 241(04): 545-548
DOI: 10.1055/a-2243-4802
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Ocular Manifestations in a Context of Primary Hyperparathyroidism: A Report of Two Cases

Augenmanifestationen im Zusammenhang mit primärem Hyperparathyreoidismus: Ein Bericht über zwei Fälle
Mickael Barbosa
1   Swiss Visio Retina Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland
,
Yannic Pannatier-Schuetz
1   Swiss Visio Retina Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland
,
Anna Chiara Nascimbeni
1   Swiss Visio Retina Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland
,
Daniela Gallo Castro
1   Swiss Visio Retina Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland
,
Nicolas Owlya
1   Swiss Visio Retina Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland
,
Aude Ambresin
1   Swiss Visio Retina Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland
2   RétinElysée, Lausanne, Switzerland
› Author Affiliations

Background

Several endocrine pathologies are commonly associated with ophthalmic involvement, such as diabetes and Gravesʼ disease [1]. The parathyroid glands produce parathyroid hormone (PTH), which plays a key role in the regulation of calcium and phosphate levels in the blood. Dysfunction of these small endocrine glands can lead to various systemic manifestations [2]. However, there is limited clinical information regarding a possible association between ocular manifestations and parathyroid gland disorders [3], [4].

We report here two cases of eye-related conditions associated with a history of primary hyperparathyroidism.



Publication History

Received: 28 October 2023

Accepted: 03 January 2024

Article published online:
23 April 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Chopra R, Chander A, Jacob JJ. The eye as a window to rare endocrine disorders. Indian J Endocrinol Metab 2012; 16: 331-338
  • 2 Michels TC, Kelly KM. Parathyroid disorders. Am Fam Physician 2013; 88: 249-257
  • 3 Golan A, Savir H, Bar-Meir S. et al. Band keratopathy due to hyperparathyroidism. Ophthalmologica 1975; 171: 119-122
  • 4 Lee DK, Eiferman RA. Ocular calcifications in primary hyperparathyroidism. Arch Ophthalmol 2006; 124: 136-137
  • 5 Wong S, Zakov ZN, Albert DM. Scleral and choroidal calcifications in a patient with pseudohypoparathyroidism. Br J Ophthalmol 1979; 63: 177-180
  • 6 Battaglia Parodi M, Arrigo A, Pina A. et al. Choroidal neovascularization complicating sclerochoroidal calcifications. Am J Ophthalmol Case Rep 2021; 24: 101235
  • 7 Thomson AC, Brown GT, Dolores-Rodriguez A. et al. A Case of Extensive Bilateral Idiopathic Sclerochoroidal Calcification and Review of Literature. Int Med Case Rep J 2021; 14: 749-755
  • 8 Honavar SG, Shields CL, Demirci H. et al. Sclerochoroidal calcification: clinical manifestations and systemic associations. Arch Ophthalmol 2001; 119: 833-840
  • 9 Shields CL, Hasanreisoglu M, Saktanasate J. et al. Sclerochoroidal calcification: clinical features, outcomes, and relationship with hypercalcemia and parathyroid adenoma in 179 eyes. Retina 2015; 35: 547-554
  • 10 Marchini G, Tosi R, Parolini B. et al. Choroidal calcification in Bartter syndrome. Am J Ophthalmol 1998; 126: 727-729
  • 11 Vezzoli G, Soldati L, Jansen A. et al. Choroidal calcifications in patients with Gitelmanʼs syndrome. Am J Kidney Dis 2000; 36: 855-858
  • 12 Zarnegar A, Ong J, Matsyaraja T. et al. Pathomechanisms in central serous chorioretinopathy: A recent update. Int J Retina Vitreous 2023; 9: 3
  • 13 Nathaniel Roybal C, Sledz E, Elshatory Y. et al. Dysfunctional autonomic regulation of the choroid in central serous chorioretinopathy. Retina 2018; 38: 1205-1210
  • 14 Cardillo Piccolino F, Lupidi M, Cagini C. et al. Choroidal Vascular Reactivity in Central Serous Chorioretinopathy. Invest Ophthalmol Vis Sci 2018; 59: 3897-3905
  • 15 Jain M, Mohan S, van Dijk EHC. Central serous chorioretinopathy: Pathophysiology, systemic associations, and a novel etiological classification. Taiwan J Ophthalmol 2022; 12: 381-393
  • 16 Fisher SB, Perrier ND. Primary hyperparathyroidism and hypertension. Gland Surg 2020; 9: 142-149
  • 17 Pepe J, Cipriani C, Sonato C. et al. Cardiovascular manifestations of primary hyperparathyroidism: a narrative review. Eur J Endocrinol 2017; 177: R297-R308
  • 18 Sabbadin C, Donà G, Bordin L. et al. Transient hypercortisolism and symptomatic hyperthyroidism associated to primary hyperparathyroidism in an elderly patient: case report and literature review. BMC Endocr Disord 2015; 15: 4
  • 19 van Rijssen TJ, van Dijk EHC, Yzer S. et al. Central serous chorioretinopathy: Towards an evidence-based treatment guideline. Prog Retin Eye Res 2019; 73: 100770