Metal-Free N-Formylation of Amines Using Carbohydrates as C1 Synthon via C–C Bond Cleavage

Abstract

Formamide group is an important part of many drug molecules, and herein a process for N-formylation of amines using carbohydrates as the C1 synthon under oxidative metal-free reaction conditions has been reported for the first time. Literature syntheses of formamides uses toxic, moisture sensitive and costly reagents under harsh reaction conditions. Our metal-free formylation is a facile, economical, and an efficient process of broad substrate scope that has led to the synthesis of thirty-three N-formylated compounds in excellent isolated yields.

Key words

N-formylation - C1 synthon - metal-free - d-glucose

Publikationsverlauf

Eingereicht: 31. Oktober 2023

Angenommen nach Revision: 10. Januar 2024

Accepted Manuscript online:
10. Januar 2024

Artikel online veröffentlicht:
07. Februar 2024

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