Subscribe to RSS
DOI: 10.1055/a-2238-4186
Incidental Papillary Thyroid Carcinoma Detected by Ga-68 DOTATATE PET/CT: A Rare Case Study and Clinical Considerations
Inzidentelles papilläres Schilddrüsenkarzinom, entdeckt durch Ga-68-DOTATATE-PET/CT: eine seltene Fallstudie und klinische ÜberlegungenIn this study, we present in detail a case of a thyroid nodule presenting with gastric neuroendocrine tumor (NET), which was incidentaly detected during a Gallium-68 (Ga-68) DOTATATE positron emission tomography/computed tomography (PET/CT) scan for staging and subsequently identified as papillary thyroid carcinoma on pathological examination. This rare case demonstrates that DOTATATE uptake can occur not only in NETs but also in thyroid cancers. This study emphasizes the importance of Fine Needle Aspiration Biopsy (FNA), especially in incidental thyroid nodules. It also highlights the place of Ga-68 DOTATATE PET/CT in clinical practice and the importance of further research in this field.
Publication History
Received: 12 December 2023
Accepted: 03 January 2024
Article published online:
23 January 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Sanabria A, Kowalski LP, Shah JP. et al. Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis. Head Neck 2018; 40: 855-866 DOI: 10.1002/hed.25029. (PMID: 29206325)
- 2 Nguyen XV, Job J, Fiorillo LE. et al. Thyroid Incidentalomas: Practice Considerations for Radiologists in the Age of Incidental Findings. Radiol Clin North Am 2020; 58: 1019-1031 DOI: 10.1016/j.rcl.2020.06.005. (PMID: 33040845)
- 3 Pauwels E, Cleeren F, Bormans G. et al. Somatostatin receptor PET ligands – the next generation for clinical practice. Am J Nucl Med Mol Imaging 2018; 8: 311-331 (PMID: 30510849)
- 4 Ambrosini V, Fanti S. 68Ga-DOTA-peptides in the diagnosis of NET. PET Clin 2014; 9: 37-42 DOI: 10.1016/j.cpet.2013.08.007. (PMID: 25029932)
- 5 Atkinson H, England JA, Rafferty A. et al. Somatostatin receptor expression in thyroid disease. Int J Exp Pathol 2013; 94: 226-229 DOI: 10.1111/iep.12024. (PMID: 23672766)
- 6 Deppen SA, Liu E, Blume JD. et al. Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors. J Nucl Med 2016; 57: 708-714 DOI: 10.2967/jnumed.115.163865. (PMID: 26769865)
- 7 Sancak S, Hardt A, Singer J. et al. Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. Thyroid 2010; 20: 505-511 DOI: 10.1089/thy.2009.0203.
- 8 Nockel P, Millo C, Keutgen X. et al. The Rate and Clinical Significance of Incidental Thyroid Uptake as Detected by Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography. Thyroid 2016; 26: 831-835 DOI: 10.1089/thy.2016.0174. (PMID: 27094616)
- 9 Kohlenberg JD, Panda A, Johnson GB. et al. Radiologic and clinicopathologic characteristics of thyroid nodules with focal 68Ga-DOTATATE PET activity. Nucl Med Commun 2021; 42: 510-516 DOI: 10.1097/MNM.0000000000001356.
- 10 Kunikowska J, Matyskiel R, Zemczak A. et al. How often do we see incidental 68Ga-DOTATATE thyroid uptake in PET/CT in patients with neuroendocrine tumours?. Endokrynol Pol 2015; 66: 231-236 DOI: 10.5603/EP.2015.0030.