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Drug Res (Stuttg) 2024; 74(03): 123-132
DOI: 10.1055/a-2237-8566
Review

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status

Saad Mohammed
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Tarique Mahmood
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Arshiya Shamim
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Farogh Ahsan
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Mohammad Shariq
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Saba Parveen
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Rufaida Waseem
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Aditya Singh
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
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Correction: Encyclopaedic Review of Glipizide Pre-clinical and Clinical StatusDrug Res (Stuttg) 2024; 74(03): e2-e2
DOI: 10.1055/a-2321-8886

Abstract

Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2 diabetes. This study compiles exhaustively all accessible information on glipizide, from preclinical to clinical studies. Glipizide may be used in concert with TRAIL to treat cancer cells; in vitro studies have shown that it suppresses angiogenesis and vasculogenesis while shielding cells from glycation-induced damage. Anticonvulsant effects and modifications in the pharmacokinetics of other medications, such as Divalproex Sodium, were seen in glipizide in vivo experiments. Propranolol amplifies glipizide's hypoglycemic effect briefly in normal animals but consistently enhances it in diabetic ones. In the treatment of cancer and neurodegenerative poly(Q) illnesses, glipizide has demonstrated to offer potential therapeutic advantages. It is ineffective in preventing DENA-induced liver cancer and may cause DNA damage over time. The way glipizide interacts with genetic variants may increase the risk of hypoglycemia. Combining Syzygium cumini and ARBE to glipizide may enhance glycemic and lipid control in type 2 diabetes. Individuals with coronary artery disease who take glipizide or glyburide have an increased risk of death. The risk of muscular responses and acute pancreatitis is minimal when glipizide and dulaglutide are combined. In conclusion, glipizide has shown promising therapeutic efficacy across a variety of disorders.

Keywords

pharmacology - insulin / glucagons - drug research - antidiabetic drugs


Publication History

Received: 11 July 2023

Accepted: 01 January 2024

Article published online:
26 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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