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Klin Monbl Augenheilkd 2024; 241(05): 619-625
DOI: 10.1055/a-2218-0237
DOI: 10.1055/a-2218-0237
Übersicht
Ocular Involvement in Graft-versus-Host Disease
Article in several languages: deutsch | English
Abstract
In ocular graft-versus-host disease (GVHD), an inflammatory reaction occurs at the ocular surface after transplantation of allogeneic hematopoietic stem cells. Self-reactive T cells of the donor are particularly responsible for this. This can lead to a pronounced wetting disorder of the ocular surface, conjunctival hyperemia, and corneal ulceration up to perforation. The ocular GVHD is associated with a high degree of suffering, such as pain, photophobia, and reduction in visual acuity. This review provides an overview of typical ophthalmological findings, topical and systemic therapeutic approaches, and concomitant measures (e.g., scleral lenses, punctum plugs) and the appropriate management of complications.
Key words
graft-versus-host disease (GVHD) - allogeneic hematopoietic cell transplantation (HCT) - diagnosis - classification - therapyPublication History
Received: 06 November 2023
Accepted: 21 November 2023
Article published online:
23 January 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
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