Neue Therapieansätze bei Multipler Sklerose inkl. Stellenwert älterer Präparate

Kaum andere medizinische Fachrichtungen haben sie derart entwickelt wie die Neurologie – besondere Fortschritte in der Behandlung der Multiplen Sklerose (MS) sind festzuhalten. Krankheitsmodifizierende Therapien (DMT) ermöglichen eine hocheffektive Beeinflussung des Krankheitsverlaufs. Dieser Beitrag versucht einen Überblick geben, welche Immuntherapeutika zur individualisierten Behandlung von MS-Patienten zur Verfügung stehen und praktische Hinweise für deren Anwendung.

Abstract

The landscape of immunotherapies in the management of Multiple Sclerosis (MS) is currently particularly dynamic. Over 21 immunotherapeutic options are approved by the European Meidcines Agency (EMA), Food and Drug Administration (FDA) and newer approaches are ongoing in clinical trials. With advancements in the understanding of MS pathophysiology and further development of diagnosis criteria, newer and more specific disease-modifying therapies (DMTs) have emerged in recent years. The selection and timing of proper therapeutic approaches is increasingly complex. We provide an overview of the available immunotherapies for a personalized MS treatment and discuss practical insights into their application. The importance of early intervention, distinction between escalation and induction approaches, and consideration of high-efficacy treatments for specific patient groups are in discussed. We emphasize the significance of a patient-centered approach, taking into account various factors such as comorbidities, family planning, administration preferences and potential side effects in treatment decision-making.

Schlüsselwörter

Multiple Sklerose - Immuntherapie - krankheitsmodifizierende Therapien - personalisierte Behandlung - monoklonale Antikörper.

Key word

Multiple Sclerosis - Immunotherapy - Disease-Modifying Therapies - Personalized Treatment - monoclonal antibodies.

Publication History

Article published online:
25 January 2024

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