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CC BY-NC-ND 4.0 · J Neurol Surg Rep 2023; 84(03): e103-e108
DOI: 10.1055/a-2161-7710
Case Report

A Primary Intraosseous Meningioma: A Rare Case of Malignancy with High Proliferative Ability

Yoshiki Sato
1   Division of Neurosurgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
,
Koichi Mitsuya 
1   Division of Neurosurgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
,
Yuko Kakuda
2   Division of Diagnostic Pathology, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
,
Takuma Oishi
2   Division of Diagnostic Pathology, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
,
Shoichi Deguchi
1   Division of Neurosurgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
,
Takashi Sugino 
2   Division of Diagnostic Pathology, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
,
Yasuto Akiyama
3   Division of Immunotherapy, Shizuoka Cancer Center Research Institute, Nagaizumi, Shizuoka, Japan
,
Takeshi Nagashima
4   Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Nagaizumi, Shizuoka, Japan
5   SRL, Tokyo, Japan
,
Kenichi Urakami
6   Medical Genetics Division, Shizuoka Cancer Center Research Institute, Nagaizumi, Shizuoka, Japan
,
Yuji Shimoda
3   Division of Immunotherapy, Shizuoka Cancer Center Research Institute, Nagaizumi, Shizuoka, Japan
5   SRL, Tokyo, Japan
,
Keiichi Ohshima
7   Division of Medical Genetics Division, Shizuoka Cancer Center Research Institute, Nagaizumi, Shizuoka, Japan
,
Nakamasa Hayashi
1   Division of Neurosurgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
,
Ken Yamaguchi
8   Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan
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Abstract

Primary intraosseous meningioma (PIM) is a rare tumor that arises in the skull. Histopathologically, it is generally described as a slow-growing, benign lesion. However, on rare occasions, PIM presents as a malignancy with high proliferative ability, which requires maximal resection, adjuvant radiotherapy, and subsequent careful follow-up. Because of the rarity of such cases, they present a diagnostic challenge with unusual pathological findings. Herein, we report a case of a primary intraosseous anaplastic meningioma with extensive invasion inside and outside the skull, along with the results of whole-genome analysis. Histopathological diagnosis was a World Health Organization grade 3 anaplastic meningioma. In the literature, only two cases of anaplastic PIM have been reported, so its characteristics and treatment are poorly understood. Our patient was successfully treated with tumor resection, followed by intensity-modulated radiation therapy. Follow-up imaging studies revealed no recurrence or distant metastasis, including to lung, liver, and bone, at 8 months after the surgery.

Keywords

meningioma - intraosseous - anaplastic - extensive invasion - genetic analysis


Publikationsverlauf

Eingereicht: 12. Januar 2023

Angenommen: 06. August 2023

Accepted Manuscript online:
29. August 2023

Artikel online veröffentlicht:
27. September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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