Rofo 2024; 196(03): 254-261
DOI: 10.1055/a-2130-3162
Review

Forensic Diagnostics of the Skeletal Age in the Living – Backgrounds and Methodology

Article in several languages: English | deutsch
Daniel Wittschieber
1   Institute of Forensic Medicine, University Hospital Bonn, Germany
,
Maria Luise Hahnemann
2   Department of Neuroradiology, University Hospital Bonn, Bonn, Germany
,
Hans-Joachim Mentzel
3   Institute of Diagnostic and Interventional Radiology, Section of Pediatric Radiology, Jena University Hospital, Jena, Germany
› Author Affiliations

Abstract

Background The expert opinions on forensic age diagnostics requested by state institutions are used to show the exceeding of legally relevant age thresholds, especially the completed 18th year of life. According to the recommendations of the Study Group on Forensic Age Diagnostics (AGFAD), this requires – among other things – a determination of skeletal age.

Method Considering recent scientific knowledge, the current conditions and established skeletal age diagnostics methods are presented. Additionally, this review article sheds light on the influence of ethnicity and socioeconomic status, questions regarding indication, as well as alternative and future developments.

Results and Conclusion In forensic age diagnostics, particularly hand radiography and thin-slice CT of the medial clavicular epiphysis are relevant for determining skeletal age. The Atlas method of Greulich and Pyle (1959) and the clavicular stages by Schmeling et al. (2004) and Kellinghaus et al. (2010) are primarily used for this. This spectrum of methods, which is based on a very solid database, might be supplemented by MRI studies of the knee joint in the near future.

Key Points:

  • Determining skeletal age is an essential part of forensic age diagnostics commissioned by state authorities and courts.

  • Hand radiography and CT of the medial clavicular epiphysis form the core of the spectrum of methods recommended by the Study Group of Forensic Age Diagnostics (AGFAD).

  • Since the radiological studies required for forensic age diagnostics are not medically indicated, it must be ensured that the legal basis is specifically named in each case when commissioning expert opinions.

  • MRI studies of the knee joint might increase the spectrum of methods in the near future.

Citation Format

  • Wittschieber D, Hahnemann ML, Mentzel H. Forensic Diagnostics of the Skeletal Age in the Living – Backgrounds and Methodology. Fortschr Röntgenstr 2024; 196: 254 – 261



Publication History

Received: 04 January 2023

Accepted: 04 July 2023

Article published online:
12 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Mentzel HJ, Wittschieber D. Radiologische Methoden zur Altersdiagnostik: Klinische und forensische Aspekte. Radiologie (Heidelb) 2023; 63: 129-140
  • 2 Hagen M, Schmidt S, Schulz R. et al. Forensic age assessment of living adolescents and young adults at the Institute of Legal Medicine, Münster, from 2009 to 2018. Int J Legal Med 2020; 134: 745-751
  • 3 Taranilla Castro AM, Pujol-Robinat A, Badía García MA. et al. Forensic age estimation in Barcelona: analysis of expert reports issued between 2011 and 2018. Int J Legal Med 2023; 137: 395-402
  • 4 Schmeling A, Dettmeyer R, Rudolf E. et al. Forensic Age Estimation. Dtsch Arztebl Int 2016; 113: 44-50
  • 5 Schmeling A, Kreitner KF, Heindel W. et al. Bildgebung zur forensischen Altersdiagnostik bei Jugendlichen und jungen Erwachsenen. Radiologie up2date 2019; 19: 63-75
  • 6 Parzeller M. Rechtliche Aspekte der forensischen Altersdiagnostik. Rechtsmedizin 2010; 21: 12-21
  • 7 Vorstand der Deutschen Gesellschaft für Rechtsmedizin (DGRM). Stellungnahme: Forensische Altersdiagnostik bei unbegleiteten minderjährigen Flüchtlingen. 02.05.2018. https://www.dgrm.de/news/stellungnahmen/stellungnahme-forensische-altersdiagnostik-bei-unbegleiteten-minderjaehrigen-fluechtlingen Last Access: 07 May 2023
  • 8 Parzeller M. Juristische Aspekte der forensischen Altersdiagnostik. Rechtsprechung-Update 2010–2014. Rechtsmedizin 2015; 25: 21-29
  • 9 Schmeling A, Grundmann C, Fuhrmann A. et al. Criteria for age estimation in living individuals. Int J Legal Med 2008; 122: 457-460
  • 10 Schumacher G, Schmeling A, Rudolf E. Medical age assessment of juvenile migrants: an analysis of age marker-based assessment criteria. Publications Office of the European Union, Luxembourg 2018; DOI: 10.2760/47096.
  • 11 Schmeling A, Reisinger W, Loreck D. et al. Effects of ethnicity on skeletal maturation: consequences for forensic age estimations. Int J Legal Med 2000; 113: 253-258
  • 12 Meijerman L, Maat GJ, Schulz R. et al. Variables affecting the probability of complete fusion of the medial clavicular epiphysis. Int J Legal Med 2007; 121: 463-468
  • 13 Schmeling A, Olze A, Reisinger W. et al. Der Einfluss der Ethnie auf die bei strafrechtlichen Altersschätzungen untersuchten Merkmale. Rechtsmedizin 2001; 11: 78-81
  • 14 Olze A, Schmeling A, Taniguchi M. et al. Forensic age estimation in living subjects: the ethnic factor in wisdom tooth mineralization. Int J Legal Med 2004; 118: 170-173 
  • 15 Olze A, Bilang D, Schmidt S. et al. Validation of common classification systems for assessing the mineralization of third molars. Int J Legal Med 2005; 119: 22-26
  • 16 Schmeling A, Schulz R, Danner B. et al. The impact of economic progress and modernization in medicine on the ossification of hand and wrist. Int J Legal Med 2006; 120: 121-126
  • 17 Timme M, Steinacker JM, Schmeling A. Age estimation in competitive sports. Int J Legal Med 2017; 131: 225-233
  • 18 Schmeling A. Forensische Altersdiagnostik bei lebenden Jugendlichen und jungen Erwachsenen. Rechtsmedizin 2011; 21: 151-162
  • 19 Tisè M, Mazzarini L, Fabrizzi G. et al. Applicability of Greulich and Pyle method for age assessment in forensic practice on an Italian sample. Int J Legal Med 2011; 125: 411-416
  • 20 Olze A, Solheim T, Schulz R. et al. Evaluation of the radiographic visibility of the root pulp in the lower third molars for the purpose of forensic age estimation in living individuals. Int J Legal Med 2010; 124: 183-186
  • 21 Schmeling A, Schmidt S, Schulz R. et al. Studienlage zum zeitlichen Verlauf der Schlüsselbeinossifikation. Rechtsmedizin 2014; 24: 467-474
  • 22 Pelech L, Pechstein J. Vergleichende Untersuchungen über die Entwicklung des Skelettalters bei tschechischen und süddeutschen Kindern. Arztl Jugendkd 1976; 67: 23-28
  • 23 Schmidt S, Fracasso T, Pfeiffer H. et al. Skelettaltersbestimmung der Hand. Rechtsmedizin 2010; 20: 475-482
  • 24 Greulich WW, Pyle SI. Radiographic atlas of skeletal development of the hand and wrist. Stanford: Stanford University Press; 1959: 256
  • 25 Thiemann HH, Nitz I, Schmeling A. Röntgenatlas der normalen Hand im Kindesalter. Stuttgart: Thieme; 2006: 149
  • 26 Roche AF, Chumlea WC, Thissen D. Assessing the skeletal maturity of the hand-wrist: Fels method. Springfield: Thomas; 1988: 339
  • 27 Gilsanz V, Ratib O. Hand bone age. A digital atlas of skeletal maturity. Berlin Heidelberg New York Tokio: Springer; 2005: 92
  • 28 Tanner JM, Whitehouse RH, Marshall WA. et al. Assessment of skeletal maturity and prediction of adult height (TW2 method). 2nd ed.. London: Academic Press; 1983: 106
  • 29 Tanner JM, Healy MJR, Goldstein H. et al. Assessment of skeletal maturity and prediction of adult height (TW3 method). London: Saunders; 2001: 128
  • 30 Baumann U, Schulz R, Reisinger W. et al. Reference study on the time frame for ossification of the distal radius and ulnar epiphyses on the hand radiograph. Forensic Sci Int 2009; 191: 15-18
  • 31 Schmidt S, Nitz I, Ribbecke S. et al. Skeletal age determination of the hand: a comparison of methods. Int J Legal Med 2013; 127: 691-698
  • 32 van Rijn RR, Lequin MH, Robben SG. et al. Is the Greulich and Pyle atlas still valid for Dutch Caucasian children today?.  Pediatric Radiology 2001;  31: 748-752 
  • 33 Schmidt S, Koch B, Schulz R. et al. Studies in use of the Greulich-Pyle skeletal age method to assess criminal liability. Leg Med (Tokyo) 2008; 10: 190-195
  • 34 Cunningham C, Scheuer L, Black S. Developmental juvenile osteology. 2nd ed.. San Diego: Academic Press; 2016: 630
  • 35 Schmeling A, Schulz R, Reisinger W. et al. Studies on the time frame for ossification of the medial clavicular epiphyseal cartilage in conventional radiography. Int J Legal Med 2004; 118: 5-8
  • 36 Kellinghaus M, Schulz R, Vieth V. et al. Enhanced possibilities to make statements on the ossification status of the medial clavicular epiphysis using an amplified staging scheme in evaluating thin-slice CT scans. Int J Legal Med 2010; 124: 321-325
  • 37 Wittschieber D, Schulz R, Pfeiffer H. et al. Systematic procedure for identifying the five main ossification stages of the medial clavicular epiphysis using computed tomography: a practical proposal for forensic age diagnostics. Int J Legal Med 2017; 131: 217-224
  • 38 Scharte P, Vieth V, Schulz R. et al. Comparison of imaging planes during CT-based evaluation of clavicular ossification: a multi-center study. Int J Legal Med 2017; 131: 1391-1397
  • 39 Mühler M, Schulz R, Schmidt S. et al. The influence of slice thickness on assessment of clavicle ossification in forensic age diagnostics. Int J Legal Med 2006; 120: 15-17
  • 40 Wittschieber D, Schulz R, Vieth V. et al. Influence of the examinerʼs qualification and sources of error during stage determination of the medial clavicular epiphysis by means of computed tomography. Int J Legal Med 2014; 128: 183-191
  • 41 Kellinghaus M, Schulz R, Vieth V. et al. Forensic age estimation in living subjects based on the ossification status of the medial clavicular epiphysis as revealed by thin-slice multidetector computed tomography. Int J Legal Med 2010; 124: 149-154
  • 42 Wittschieber D, Schulz R, Vieth V. et al. The value of sub-stages and thin slices for the assessment of the medial clavicular epiphysis: a prospective multi-center CT study. Forensic Sci Med Pathol 2014; 10: 163-169
  • 43 Wittschieber D, Schmidt S, Vieth V. et al. Subclassification of clavicular substage 3a is useful for diagnosing the age of 17 years. Rechtsmedizin 2014; 24: 485-488
  • 44 Ekizoglu O, Hocaoglu E, Inci E. et al. Estimation of forensic age using substages of ossification of the medial clavicle in living individuals. Int J Legal Med 2015; 129: 1259-1264
  • 45 Hermetet C, Saint-Martin P, Gambier A. et al. Forensic age estimation using computed tomography of the medial clavicular epiphysis: a systematic review. Int J Legal Med 2018; 132: 1415-1425
  • 46 Bassed RB, Drummer OH, Briggs C. et al. Age estimation and the medial clavicular epiphysis: analysis of the age of majority in an Australian population using computed tomography. Forensic Sci Med Pathol 2011; 7: 148-154
  • 47 Pattamapaspong N, Madla C, Mekjaidee K. et al. Age estimation of a Thai population based on maturation of the medial clavicular epiphysis using computed tomography. Forensic Sci Int 2015; 246: 123.e1–5
  • 48 Schmeling A. Die aktuelle medizinethische Debatte über die forensische Altersdiagnostik bei unbegleiteten minderjährigen Flüchtlingen. Masterarbeit, 01.10.2018. https://www.dgrm.de/fileadmin/PDF/AG_FAD/masterarbeit_schmeling.pdf Last Access: 07 May 2023
  • 49 Rudolf E, Kramer J, Schmidt S. et al. Intraindividual incongruences of medially ossifying clavicles in borderline adults as seen from thin-slice CT studies of 2595 male persons. Int J Legal Med 2018; 132: 629-636
  • 50 Befurt L, Kirchhoff G, Rudolf E. et al. Juristische Aspekte der forensischen Altersdiagnostik auf der Grundlage des § 42f SGB VIII. Rechtsmedizin 2020; 30: 241-248
  • 51 Bontrager KL, Lampignano JP. Textbook of radiographic positioning and related anatomy. St. Louis: Mosby/Elsevier. 2009
  • 52 Wittschieber D, Ottow C, Vieth V. et al. Projection radiography of the clavicle: still recommendable for forensic age diagnostics in living individuals?. Int J Legal Med 2015; 129: 187-193
  • 53 Schmeling A, Reisinger W, Wormann D. et al. Strahlenexposition bei Röntgenuntersuchungen zur forensischen Altersschätzung Lebender. Rechtsmedizin 2000; 10: 135-137
  • 54 Meier N, Schmeling A, Loose R. et al. Altersdiagnostik und Strahlenexposition. Rechtsmedizin 2015; 25: 30-33
  • 55 Wittschieber D, Vieth V, Domnick C. et al. The iliac crest in forensic age diagnostics: evaluation of the apophyseal ossification in conventional radiography. Int J Legal Med 2013; 127: 473-479
  • 56 Wittschieber D, Schmeling A, Schmidt S. et al. The Risser sign for forensic age estimation in living individuals: a study of 643 pelvic radiographs. Forensic Sci Med Pathol 2013; 9: 36-43
  • 57 Schulz R, Schmidt S, Pfeiffer H. et al. Sonographische Untersuchungen verschiedener Skelettregionen. Forensische Altersdiagnostik bei lebenden Jugendlichen und jungen Erwachsenen. Rechtsmedizin 2014; 24: 480-484
  • 58 De Tobel J, Bauwens J, Parmentier GIL. et al. Magnetic resonance imaging for forensic age estimation in living children and young adults: a systematic review. Pediatr Radiol 2020; 50: 1691-1708
  • 59 Ottow C, Kramer JA, Olze A. et al. Magnetic resonance tomography studies on age estimation of unaccompanied minor refugees. Rechtsmedizin 2015; 25: 12-20
  • 60 Schmidt S, Henke CA, Wittschieber D. et al. Optimising magnetic resonance imaging-based evaluation of the ossification of the medial clavicular epiphysis: a multi-centre study. Int J Legal Med 2016; 130: 1615-1621
  • 61 Schmidt S, Ottow C, Pfeiffer H. et al. Magnetic resonance imaging-based evaluation of ossification of the medial clavicular epiphysis in forensic age assessment. Int J Legal Med 2017; 131: 1665-1673
  • 62 Vieth V, Schulz R, Heindel W. et al. Forensic age assessment by 3.0T MRI of the knee: proposal of a new MRI classification of ossification stages. Eur Radiol 2018; 28: 3255-3262
  • 63 Wittschieber D, Chitavishvili N, Papageorgiou I. et al. Magnetic resonance imaging of the proximal tibial epiphysis is suitable for statements as to the question of majority: a validation study in forensic age diagnostics. Int J Legal Med 2022; 136: 777-784
  • 64 Chitavishvili N, Papageorgiou I, Malich A. et al. The distal femoral epiphysis in forensic age diagnostics: studies on the evaluation of the ossification process by means of T1‑ and PD/T2‑weighted magnetic resonance imaging. Int J Legal Med 2023; 137: 427-435
  • 65 Ottow C, Schmidt S, Schulz R. et al. Forensische Altersdiagnostik mittels Niederfeld-Magnetresonanztomographie. Rechtsmedizin 2023; 33: 96-104