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CC BY-NC-ND 4.0 · Semin Liver Dis 2023; 43(03): 267-278
DOI: 10.1055/a-2128-5538
Review Article

FXR Friend-ChIPs in the Enterohepatic System

Vik Meadows
1   Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey
2   Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, New Jersey
,
Zhenning Yang
1   Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey
2   Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, New Jersey
,
Veronia Basaly
1   Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey
2   Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, New Jersey
,
Grace L. Guo
1   Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey
2   Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, New Jersey
3   Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey
› Author Affiliations Funding This work was supported by the National Institutes of Health (grants: ES007148, ES029258, DK122725, GM135258, AND GM093854), the Department of Veteran Affairs (BX002741), and the Momental Foundation Mistletoe Research Fellowship (FP00032129). The authors would like to thank Rulaiha Elizabeth Taylor, Zakiyah Henry, and Dr. Bo Kong for their support to this work and Dr. Saskia van Mil for her permission to reuse two figure panels of FXR binding motif sequences found in [Fig. 1].
› Further Information
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Abstract

Chronic liver diseases encompass a wide spectrum of hepatic maladies that often result in cholestasis or altered bile acid secretion and regulation. Incidence and cost of care for many chronic liver diseases are rising in the United States with few Food and Drug Administration-approved drugs available for patient treatment. Farnesoid X receptor (FXR) is the master regulator of bile acid homeostasis with an important role in lipid and glucose metabolism and inflammation. FXR has served as an attractive target for management of cholestasis and fibrosis; however, global FXR agonism results in adverse effects in liver disease patients, severely affecting quality of life. In this review, we highlight seminal studies and recent updates on the FXR proteome and identify gaps in knowledge that are essential for tissue-specific FXR modulation. In conclusion, one of the greatest unmet needs in the field is understanding the underlying mechanism of intestinal versus hepatic FXR function.

Keywords

bile acids - farnesoid X receptor - proteome - tissue-specific FXR functions


Publication History

Accepted Manuscript online:
13 July 2023

Article published online:
11 August 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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