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Exp Clin Endocrinol Diabetes 2023; 131(10): 548-553
DOI: 10.1055/a-2123-0734
Article

Potentially Inappropriate Medication Use Among Older Patients with Diabetes in a Chinese Community

Xingxing Zhao
1   The Second Outpatient Department, Peking University Third Hospital, Beijing China
,
Lei Li
1   The Second Outpatient Department, Peking University Third Hospital, Beijing China
,
Xiujun Guo
1   The Second Outpatient Department, Peking University Third Hospital, Beijing China
,
Jianqiang Wang
1   The Second Outpatient Department, Peking University Third Hospital, Beijing China
,
Yingying Yan
2   Department of Pharmacy, Peking University Third Hospital, Beijing, China
,
Yunyi Le
3   Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China
› Author Affiliations Fundings This study was partially supported by research grants from the National Natural Science Foundation of China (82200908). National Natural Science Foundation of China — http://dx.doi. org/10.13039/501100001809;82200908
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Abstract

Background Potentially inappropriate medications (PIMs) are frequently prescribed to older people with diabetes. This study aimed to assess the prevalence of PIM use in older people with diabetes and identify potential risk factors influencing the development of PIM use.

Methods This was a cross-sectional study conducted in an outpatient setting in Beijing, China, using Chinese criteria. The prevalence of PIM use, polypharmacy, and comorbidities in older adults with diabetes in an outpatient setting was measured. Logistic models were employed to investigate the association among polypharmacy, comorbidities, and PIM use.

Results The prevalence of PIM use and polypharmacy was 50.1% and 70.8%, respectively. The most common comorbidities were hypertension (68.0%), hyperlipemia (56.6%), and stroke (36.3%), and the top three inappropriately used medications were insulin (22.0%), clopidogrel (11.9%), and eszopiclone (9.81%). Age (OR 1.025; 95% CI 1.009, 1.042), the number of diagnoses (OR 1.172; 95% CI 1.114, 1.232), coronary heart disease (OR 1.557; 95% CI 1.207, 2.009), and polypharmacy (OR 1.697; 95% CI 1.252, 2.301) were associated with PIM use.

Conclusions Given the higher rate of PIM use among older adults with diabetes, strategies and interventions targeting this population are needed to minimize PIM use.

Key words

diabetes - polypharmacy - potentially inappropriate medication (PIM) - comorbidities


Publication History

Received: 27 April 2023
Received: 31 May 2023

Accepted: 29 June 2023

Accepted Manuscript online:
04 July 2023

Article published online:
06 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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