Palladium-Catalyzed Synthesis of Benzofuran Spiroketals Derived from Cholesterol; NMR and X-ray Characterization

Abstract

The synthesis of two diastereomeric steroid spiroketals bearing a 2,3-dihydrobenzofuran moiety is described. The structure of the obtained compounds was elucidated by combined 1D and 2D NMR techniques and corroborated by X-ray crystallography studies.

Key words

steroids - benzofuran spiroketals - palladium-catalyzed spiroketalization - NMR - X-ray diffraction

Publication History

Received: 03 April 2023

Accepted after revision: 15 May 2023

Accepted Manuscript online:
15 May 2023

Article published online:
14 June 2023

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