Lipohyperplasia dolorosa – neu betrachtet

Diese Übersicht basiert auf aktuellen Daten und versucht, die emotionale Diskussion von Bertsch und Erbacher über Lipödem zu versachlichen. Fragen zur Progression und psychischen Vorbelastungen bei Lipohyperplasia dolorosa (LiDo) sind ungeklärt. Es gibt keine Belege, dass LiDo allein zu Flüssigkeitsansammlungen führt. Das „Lipolymphödem“ kombiniert LiDo und Adipositas-assoziiertes Lymphödem. Adipositas, unabhängig von LiDo, verschleiert dessen Symptome. Gewichtsverlust beeinflusst LiDo-Symptome nicht direkt, aber die Adipositas.

Schlüsselwörter

Lipödem - Ödem - Genetik - Hormone - koinzidente Adipositas

Publikationsverlauf

Artikel online veröffentlicht:
23. Oktober 2023

• Literatur

• 1 Bertsch T, Erbacher G. Lipödem – Mythen und Fakten Teil 1. Phlebologie 2018; 47: 84-92
• 2 Herpertz U. Das Lipödem – was genau ist das?. Physiotherapie 1991; 82: 191-195
• 3 Cornely M. Terminologie des Lipödems. Phlebologie 2005; 35: 271
• 4 Herpertz U. Der Missbrauch des Lipödems. Lymphol Forsch Prax 2003; 7: 90-93
• 5 Herpertz U. Das Lipödem. Z Lymphol 1995; 19: 1-11
• 6 Bertsch T, Erbacher G. Lipödem – Mythen und Fakten Teil 2. Phlebologie 2018; 47: 120-126
• 7 Bertsch T, Erbacher G. Lipödem – Mythen und Fakten Teil 3. Phlebologie 2018; 47: 188-198
• 8 Bertsch T, Erbacher G, Torio-Padron N. Lipödem – Mythen und Fakten Teil 4. Phlebologie 2019; 48: 47-56
• 9 Allen EV, Hines Jr EA. Lipedema of the legs: A syndrom characterized by fat legs and orthostatic edema. Proc Staff Meet Mayo Clin 1940; 15: 184-187
• 10 Wold LE, Hines Jr EA. Allen EV. Lipedema of the legs; a syndrome characterized by fat legs and edema. Ann Intern Med 1951; 34: 1243-1250
• 11 Hines Jr EA. Lipedema and physiologic edema. Proc Staff Meet Mayo Clin 1952; 27: 7-9
• 12 Rank BK, Wong GS. Lipoedema. Aust N Z J Surg 1966; 35: 166-169
• 13 Kundu S, Irving ER, Whittingham GE. et al. Lipoedema. Gerontol Clin (Basel) 1967; 9: 40-46
• 14 Sigg K. Lipödeme. In: Varizen· Ulcus cruris und Thrombose. Berlin, Heidelberg: Springer; 1968: 304-304
• 15 Sigg K. Lipödeme. In: Varizen· Ulcus cruris und Thrombose. Berlin, Heidelberg: Springer; 1976: 348-348
• 16 Greer KE. Lipedema of the legs. Cutis 1974; 14: 98-100
• 17 Stallworth JM, Hennigar GR, Jonsson Jr HT. et al. The chronically swollen painful extremity. A detailed study for possible etiological factors. JAMA 1974; 228: 1656-1659
• 18 Schingale FJ. Lymphödeme-Lipödeme: Diagnose und Therapie; Ein Ratgeber für Betroffene. Hannover: Schlütersche; 2002
• 19 Meier-Vollrath I, Schmeller W. Lipödem – aktueller Stand, neue Perspektiven. Lipoedema – current status, new perspectives. J Dtsch Dermatol Ges 2004; 2: 181-186
• 20 Schmeller W, Meier-Vollrath I. Lipödem – Aktuelles zu einem weitgehend unbekannten Krankheitsbild. Aktuelle Derm 2007; 33: 251-260
• 21 Vignes S. Lipedema: a misdiagnosed entity. J Mal Vasc 2012; 37: 213-218
• 22 Herbst KL, Mirkovskaya L, Bharhagava A. et al. Lipedema Fat and Signs and Symptoms of Illness, Increase with Advancing Stage. Archives of Medicine 2015; 7: 1-8
• 23 Herbst KL. Subcutaneous Adipose Tissue Diseases: Dercum Disease, Lipedema, Familial Multiple Lipomatosis, and Madelung Disease. et al. In: Feingold KR, Anawalt B, Blackman MR. . South Dartmouth (MA): MDText.com, Inc; 2019
• 24 Herbst KL, Kahn LA, Iker E. et al. Standard of care for lipedema in the United States. Phlebology 2021; 36: 779-796
• 25 Brenner E. Wie kommt der Schmerz ins Lipödem?. Lymphol Forsch Prax 2017; 21: 40-47
• 26 Erbacher G, Bertsch T. Lipoedema and Pain: What is the role of the psyche? – Results of a pilot study with 150 patients with Lipoedema. Phlebologie 2020; 49: 305-316
• 27 Blaine B. Does depression cause obesity?: A meta-analysis of longitudinal studies of depression and weight control. J Health Psychol 2008; 13: 1190-1197
• 28 Noll JG, Zeller MH, Trickett PK. et al. Obesity risk for female victims of childhood sexual abuse: a prospective study. Pediatrics 2007; 120: e61-67
• 29 Richardson AS, Dietz WH, Gordon-Larsen P. The association between childhood sexual and physical abuse with incident adult severe obesity across 13 years of the National Longitudinal Study of Adolescent Health. Pediatr Obes 2014; 9: 351-361
• 30 Gensior MHL, Cornely M. Der Lipödemschmerz, seine Folgen auf die Lebensqualität betroffener Patientinnen – Ergebnisse einer Patientenbefragung mittels Schmerzfragebogen. Handchir Mikrochir Plast Chir 2019; 51: 249-254
• 31 Chakraborty A, Crescenzi R, Usman TA. et al. Indications of Peripheral Pain, Dermal Hypersensitivity, and Neurogenic Inflammation in Patients with Lipedema. Int J Mol Sci 2022; 23: 10313
• 32 Malik RA. Pathology of human diabetic neuropathy. Handb Clin Neurol 2014; 126: 249-259
• 33 Shillo P, Yiangou Y, Donatien P. et al. Nerve and Vascular Biomarkers in Skin Biopsies Differentiate Painful From Painless Peripheral Neuropathy in Type 2 Diabetes. Front Pain Res (Lausanne) 2021; 2: 731658
• 34 Dinnendahl R, Tschimmel D, Loew V. et al. Lipedema patients show a distinctly altered Quantitative Sensory Testing (QST) profile. medRxiv 2023;
• 35 Hucho T. Lipedema pain-the neglected symptom. Dermatologie (Heidelb) 2023; 74: 575-579
• 36 Dudek JE, Bialaszek W, Ostaszewski P. Quality of life in women with lipoedema: a contextual behavioral approach. Qual Life Res 2016; 25: 401-408
• 37 Dudek JE, Bialaszek W, Ostaszewski P. et al. Depression and appearance-related distress in functioning with lipedema. Psychol Health Med 2018; 23: 846-853
• 38 Alwardat N, Di Renzo L, Alwardat M. et al. The effect of lipedema on health-related quality of life and psychological status: a narrative review of the literature. Eat Weight Disord-Stud Anorex 2020; 25: 851-856
• 39 West-Leuer B. Lipohyperplasia dolorosa : An unreasonable burden and challenge for the psychological well-being of affected patients. Dermatologie (Heidelb) 2023; 74: 580-587
• 40 Chen SG, Hsu SD, Chen TM. et al. Painful fat syndrome in a male patient. Br J Plast Surg 2004; 57: 282-286
• 41 Child AH, Gordon KD, Sharpe P. et al. Lipedema: an inherited condition. Am J Med Genet A 2010; 152A: 970-976
• 42 Fife CE, Maus EA, Carter MJ. Lipedema: a frequently misdiagnosed and misunderstood fatty deposition syndrome. Adv Skin Wound Care 2010; 23: 81-92
• 43 Bertlich M, Jakob M, Bertlich I. et al. Lipedema in a male patient: report of a rare case – management and review of the literature. GMS Interdiscip Plast Reconstr Surg DGPW 2021; 10: Doc11
• 44 Herpertz U. Entstehungszeitpunkt von Lipödemen. Lymphol Forsch Prax 2004; 8: 79-81
• 45 Marshall M, Schwahn-Schreiber C. Lymph-, Lip- und Phlebödem : Differenzialdiagnostische Abklärung mittels hochauflösender Duplexsonographie. Gefasschirurgie 2008; 13: 204-212
• 46 Marshall M, Schwahn-Schreiber C. Prävalenz des Lipödems bei berufstätigen Frauen in Deutschland. Phlebologie 2011; 40: 127-134
• 47 Amato ACM, Amato FCM, Amato JLS. et al. Lipedema prevalence and risk factors in Brazil. J Vasc Bras 2022; 21: e20210198
• 48 Kruppa P, Georgiou I, Biermann N. et al. Lipedema-Pathogenesis, Diagnosis, and Treatment Options. Dtsch Arztebl Int 2020; 117: 396-403
• 49 Deutsche Adipositas-Gesellschaft e.V. S3-Leitlinie Adipositas – Prävention und Therapie (30.04.2014). Zugriff am 09. Februar 2023 unter: https://register.awmf.org/de/leitlinien/detail/050–001
• 50 Gemeinsamer Bundesausschuss. Richtlinie Methoden vertragsärztliche Versorgung: Liposuktion bei Lipödem im Stadium III. BAnz AT 2019: 06.12.2019 B2013.
• 51 Payer L. Disease-Mongers: How doctors, drug companies and insurers are making you feel sick. New York: John Wiley & Sons; 1992
• 52 Moynihan R, Heath I, Henry D. Selling sickness: the pharmaceutical industry and disease mongering. BMJ 2002; 324: 886-891
• 53 Mendoza E. Beitrag als Diskussionsgrundlage zum Thema: Fehlinformation im Internet und Konsequenzen für Patienten und uns Ärzte im täglichen Arbeitsfeld am Beispiel des Lipödems. Phlebologie 2020; 49: 115-116
• 54 Schott G. Erfundene Krankheiten? Zur aktuellen Problematik des Disease Mongering. Arzneiverordnung in der Praxis 2015; 42: 178-183
• 55 Cornely ME. Lipohyperplasia dolorosa : About facts and fiction, clinical presentation and examination. Dermatologie (Heidelb) 2023; 74: 566-574
• 56 Paolacci S, Precone V, Acquaviva F. et al. Genetics of lipedema: new perspectives on genetic research and molecular diagnoses. Eur Rev Med Pharmacol Sci 2019; 23: 5581-5594
• 57 Precone V, Barati S, Paolacci S. et al. Genetic syndromes with localized subcutaneous fat tissue accumulation. Acta Biomed 2019; 90: 90-92
• 58 Grigoriadis D, Sackey E, Riches K. et al. Investigation of clinical characteristics and genome associations in the 'UK Lipoedema' cohort. PLoS One 2022; 17: e0274867
• 59 Yang S, Wang Y, Wang L. et al. RNA-Seq reveals differentially expressed genes affecting polyunsaturated fatty acids percentage in the Huangshan Black chicken population. PLoS One 2018; 13: e0195132
• 60 Petit MM, Schoenmakers EF, Huysmans C. et al. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. Genomics 1999; 57: 438-441
• 61 Klimentidis YC, Chen Z, Gonzalez-Garay ML. et al. Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors. Eur J Hum Genet 2022;
• 62 Michelini S, Herbst KL, Precone V. et al. A Multi-Gene Panel to Identify Lipedema-Predisposing Genetic Variants by a Next-Generation Sequencing Strategy. J Pers Med 2022; 12
• 63 Michelini S, Chiurazzi P, Marino V. et al. Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema. Int J Mol Sci 2020; 21
• 64 Joksimovic SL, Covey DF, Jevtovic-Todorovic V. et al. Neurosteroids in Pain Management: A New Perspective on an Old Player. Front Pharmacol 2018; 9: 1127
• 65 Priglinger E, Wurzer C, Steffenhagen C. et al. The adipose tissue-derived stromal vascular fraction cells from lipedema patients: Are they different?. Cytotherapy 2017; 19: 849-860
• 66 Schubert N, Viethen H. Lipödem und Liplymphödem – Alles eine Frage des Lebensstils? Ergebnisse der ersten deutschlandweiten Online-Umfrage zur Auswirkung auf die Lebensqualität der Betroffenen. Teil 1: Hintergrund, Prävalenz, medizinisch-therapeutisch-fachliche Betreuung. Lymphol Forsch Prax 2016; 20: 18-27
• 67 Grigoriadis D, Sackey E, Riches K. et al. Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort. medRxiv preprint 2021;
• 68 Al-Ghadban S, Teeler ML, Bunnell BA. Estrogen as a Contributing Factor to the Development of Lipedema. In: Heshmati HM. Hot Topics in Endocrinology and Metabolism: IntechOpen. 2021: 1-10
• 69 Szél E, Kemény L, Groma G. et al. Pathophysiological dilemmas of lipedema. Med Hypotheses 2014; 83: 599-606
• 70 Mayes JS, Watson GH. Direct effects of sex steroid hormones on adipose tissues and obesity. Obes Rev 2004; 5: 197-216
• 71 Van Pelt RE, Gozansky WS, Hickner RC. et al. Acute modulation of adipose tissue lipolysis by intravenous estrogens. Obesity (Silver Spring) 2006; 14: 2163-2172
• 72 Price TM, O'Brien SN, Welter BH. et al. Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution. Am J Obstet Gynecol 1998; 178: 101-107
• 73 Gavin KM, Cooper EE, Hickner RC. Estrogen receptor protein content is different in abdominal than gluteal subcutaneous adipose tissue of overweight-to-obese premenopausal women. Metabolism-Clinical and Experimental 2013; 62: 1180-1188
• 74 Khanna M, Qin KN, Klisak I. et al. Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization. Genomics 1995; 25: 588-590
• 75 Kalkhoff RK. Metabolic effects of progesterone. Am J Obstet Gynecol 1982; 142: 735-738
• 76 Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev 2013; 34: 309-338
• 77 Lindberg UB, Crona N, Silfverstolpe G. et al. Regional adipose tissue metabolism in postmenopausal women after treatment with exogenous sex steroids. Horm Metab Res 1990; 22: 345-351
• 78 Nono Nankam PA, Cornely M, Klöting N. et al. Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?. Front Endocrinol (Lausanne) 2022; 13: 1000094
• 79 Bertsch T, Erbacher G, Corda D. et al. Lipoedema – myths and facts, Part 5. Phlebologie 2020; 49: 31-50
• 80 Beltran K, Herbst KL. Differentiating lipedema and Dercum's disease. Int J Obes (Lond) 2017; 41: 240-245
• 81 Al-Ghadban S, Cromer W, Allen M. et al. Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue. J Obes 2019; 2019: 8747461
• 82 Felmerer G, Stylianaki A, Hagerling R. et al. Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema. J Surg Res 2020; 253: 294-303
• 83 Wolf S, Rannikko JH, Virtakoivu R. et al. A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema. Front Immunol 2022; 13: 1004609
• 84 Ishaq M, Bandara N, Morgan S. et al. Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema. Int J Obes (Lond) 2021;
• 85 Iker E, Mayfield CK, Gould DJ. et al. Characterizing Lower Extremity Lymphedema and Lipedema with Cutaneous Ultrasonography and an Objective Computer-Assisted Measurement of Dermal Echogenicity. Lymphat Res Biol 2019; 17: 525-530
• 86 Crescenzi R, Donahue PMC, Weakley S. et al. Lipedema and Dercum's Disease: A New Application of Bioimpedance. Lymphat Res Biol 2019; 17: 671-679
• 87 Crescenzi R, Marton A, Donahue PMC. et al. Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema. Obesity (Silver Spring) 2018; 26: 310-317
• 88 Suga H, Araki J, Aoi N. et al. Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration. J Cutan Pathol 2009; 36: 1293-1298
• 89 Pessentheiner AR, Ducasa GM, Gordts P. Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation. Front Immunol 2020; 11: 769
• 90 Erbacher G, Mendoza E, Bertsch T. Thigh swelling in patients with lipedema – subjective perception versus objective examination. Vasa 2022; 51: 386-388
• 91 Erbacher G, Mendoza E, Bertsch T. Schwellneigung der Oberschenkel und Hämatom­neigung bei Patientinnen mit Lipödem – Subjektive Wahrnehmung versus objektive Untersuchung. Vasomed 2023; 35: 8-17
• 92 World Health Organization. Obesity: preventing and managing the global epidemic: report of a WHO consultation. Geneva: WHO; 2000
• 93 Schmeller W, Hüppe M, Meier-Vollrath I. Langzeitveränderungen nach Liposuktion bei Lipödem. Lymphol Forsch Prax 2010; 14: 69-80
• 94 Forner-Cordero I, Pérez-Pomares MV, Forner A. et al. Prevalence of clinical manifestations and orthopedic alterations in patients with lipedema: A prospective cohort study. Lymphology 2021; 54: 170-181
• 95 Brenner E, Cornely ME. Der anthropometrische Parameter Waist to Height Ratio bei der Lipohyperplasia dolorosa vulgo Lipödem. Lymphol Forsch Prax 2022; 26: 70-78
• 96 Brenner E, Forner-Cordero I, Faerber G. et al. Body mass index vs. waist-to-height-ratio in patients with lipohyperplasia dolorosa (vulgo lipedema). J Dtsch Dermatol Ges 2023;
• 97 Reich-Schupke S. Compression therapy in obese patients. Phlebologie 2015; 44: 71-76
• 98 Kaiserling E. Lymphgefäße bei Fettgewebstumoren und tumorartigen Fettgewebsansammlungen: Immunhistochemische Studie. Lymphol Forsch Prax 2006; 10: 71-79
• 99 Reißhauer A. Physikalsiche Therapie des Lymphödems [Habilitation]. Berlin: Charité-Universitätsmedizin; 2022;
• 100 Schrader K. SPQR – Vorschlag für eine neue Klassifikation des Lipödems. Lymphol Forsch Prax 2022; 26: 98-99
• 101 Watzl B. Fundort Pflanzenzelle. Aktuelle Ernährungsmedizin 2011; 36: S2-S5
• 102 Trerotola M, Relli V, Simeone P. et al. Epigenetic inheritance and the missing heritability. Human Genomics 2015; 9: 17
• 103 Burggren WW. Dynamics of epigenetic phenomena: intergenerational and intragenerational phenotype ‘washout’. J Exp Biol 2015; 218: 80-87
• 104 Herbst KL. Rare adipose disorders (RADs) masquerading as obesity. Acta Pharmacol Sin 2012; 33: 155-172
• 105 Katzer K, Hill JL, McIver KB. et al. Lipedema and the Potential Role of Estrogen in Excessive Adipose Tissue Accumulation. Int J Mol Sci 2021; 22
• 106 Hoyt LT, Falconi AM. Puberty and perimenopause: reproductive transitions and their implications for women's health. Soc Sci Med 2015; 132: 103-112
• 107 Felmerer G, Stylianaki A, Hollmen M. et al. Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology. Sci Rep 2020; 10: 10947
• 108 Aksoy H, Karadag AS, Wollina U. Cause and management of lipedema-associated pain. Dermatol Ther 2021; 34: e14364
• 109 Marshall M, Breu FX. Differential diagnosis of lymphedema, lipedema, and phlebedema using high-resolution (duplex) ultrasound. Phlebolymphology 1999; 25: 25-32
• 110 Hirsch T, Schleinitz J, Marshall M. et al. Ist die Differenzialdiagnostik des Lipödems mittels hochauflösender Sonografie möglich?. Phlebologie 2018; 47: 182-187
• 111 Cellina M, Gibelli D, Soresina M. et al. Non-contrast MR Lymphography of lipedema of the lower extremities. Magn Reson Imaging 2020; 71: 115-124
• 112 Breu FX, Marshall M. Neue Ergebnisse der Duplex-sonographischen Diagnostik des Lip- und Lymphödems. Kompressionssonographie mit einer neuen 13 MHz-Linearsonde. Vasomed 1999; 11: 164-165
• 113 Marshall M. Differentialdiagnostische Abklärung des Lymph-, Lip- und Phlebödems mittels hochauflösender (Duplex-)Sonographie. Ultraschall Klin Prax 1996; 10: 130
• 114 Brenner E, Kröll A, Neuhüttler S. et al. Morphology of a secondary lymphedema of the leg – a correlative, cross-sectional study. Lymphology 2004; 37: 225-232
• 115 Schingale FJ, Esmer M, Küpeli B. et al. Investigation of the Less Known Effects of Manual Lymphatic Drainage: A Narrative Review. Lymphat Res Biol 2022; 20: 7-10
• 116 Atan T, Bahar-Ozdemir Y. The Effects of Complete Decongestive Therapy or Intermittent Pneumatic Compression Therapy or Exercise Only in the Treatment of Severe Lipedema: A Randomized Controlled Trial. Lymphat Res Biol 2021; 19: 86-95
• 117 Cornely ME, Hasenberg T, Cornely OA. et al. Persistent lipedema pain in patients after bariatric surgery: a case series of 13 patients. Surg Obes Relat Dis 2022; 18: 628-633
• 118 Fink JM, Schreiner L, Marjanovic G. et al. Leg Volume in Patients with Lipoedema following Bariatric Surgery. Visc Med 2021; 37: 206-211
• 119 Ng M, Fleming T, Robinson M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384: 766-781
• 120 Amann-Vesti BR, Franzeck UK, Bollinger A. Microlymphatic aneurysms in patients with lipedema. Lymphology 2001; 34: 170-175
• 121 Amann-Vesti BR, Gitzelmann G, Franzeck UK. et al. Druckmessung in den initialen Lymphgefäßen der Haut bei Patienten mit Lipödem. Lymphol Forsch Prax 2002; 6: 7-9
• 122 Brauer WJ. Altersbezogene Funktions-Lymphszintigraphie beim Lipödem und Lipolymphödem. Lymphol Forsch Prax 2000; 4: 74-77
• 123 Gould DJ, El-Sabawi B, Goel P. et al. Uncovering Lymphatic Transport Abnormalities in Patients with Primary Lipedema. J Reconstr Microsurg 2020; 36: 136-141
• 124 Tartaglione G, Visconti G, Bartoletti R. et al. Rest/stress intradermal lymphoscintigraphy in diagnosis of lipedema. World J Nucl Med 2020; 19: 376-381
• 125 Buso G, Favre L, Maufus M. et al. Indocyanine green lymphography as novel tool to assess lymphatics in patients with lipedema. Microvasc Res 2022; 140: 104298