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Synlett 2024; 35(02): 165-182
DOI: 10.1055/a-2089-4934
DOI: 10.1055/a-2089-4934
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Comparison of Diastereoselective ortho-Metalations and C–H Activations of Chiral Ferrocenes
This work was supported by the Vedecká Grantová Agentúra (Slovak Grant Agency, VEGA; grant no. VEGA 1/0804/21), and by the Operation Program of Integrated Infrastructure for the project, UpScale of Comenius University Capacities and Competence in Research, Development and Innovation, ITMS2014+: 313021BUZ3, co-financed by the European Regional Development Fund.
Abstract
Chiral ferrocene derivatives possessing a planar stereogenic unit are important as chiral catalysts and materials. The principle method to obtain 1,2-disubstituted planarly chiral ferrocenes is base-mediated ortho-metalation performed on a chiral ferrocene derivative, typically using organolithium bases. A multitude of chiral ligands and other useful compounds have been synthesized by using this methodology. Newer methodologies employing transition-metal-catalyzed C–H bond activation strategies complement ortho-metalation methods and affords access to different types of planar chiral ferrocene derivatives.
1 Introduction
2 Base-Mediated ortho-Deprotonations
3 Diastereoselective C–H Activations
4 Examples of Enantioselective C–H Activations
5 Conclusions
Publication History
Received: 20 April 2023
Accepted after revision: 09 May 2023
Accepted Manuscript online:
09 May 2023
Article published online:
16 June 2023
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