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DOI: 10.1055/a-2075-5822
Was gibt es Neues bei der Meningokokken- und Pneumokokken-Impfung?
What’s new in meningococcal and pneumococcal vaccination?
ZUSAMMENFASSUNG
Invasive Meningokokken-Infektionen gehen mit einer erhöhten Morbidität und Mortalität einher. Nach Einführung der Meningokokken-Konjugatimpfstoffe für die Serogruppen C und ACWY sowie der rekombinant hergestellten Proteinimpfstoffe für die Serogruppe B konnten in den Ländern mit entsprechenden Impfprogrammen die Fallzahlen signifikant gesenkt werden. Durch eine sich stetig verändernde Epidemiologie erscheint eine entsprechende Anpassung der Impfschemata an die nationale Infektionsdynamik sinnvoll. Die Weiterentwicklung von Kombinationsimpfstoffen wird dabei die Umsetzung effektive Impfprogramme vereinfachen.
S.-pneumoniae-Bakterien sind eine Hauptursache für (schwere) Atemwegsinfektionen und invasive Pneumokokken-Erkrankungen (IPD). Pneumokokken-Konjugatimpfstoffe (PCV) konnten die Krankheitslast in der besonders betroffenen Gruppe der Säuglinge und Kleinkinder dramatisch absenken. Neben einer relevanten Gemeinschaftsimmunität („Herdeneffekt“) musste die Zunahme von nicht in den Impfstoffen enthaltenen Serotypen (ST) beobachtet werden („replacement“). Es wurden neue, höhervalente PCV 15 und 20 entwickelt.
ABSTRACT
Invasive meningococcal disease is associated with increased morbidity and mortality. After the introduction of the meningococcal conjugate vaccines for serogroups C and ACWY as well as the recombinantly produced protein vaccines for serogroup B, the number of cases was reduced significantly in the countries with corresponding vaccination programs. Due to the constantly changing epidemiology, a corresponding adaptation of the vaccination regimen to the national infection dynamics appears to be sensible. The further development of combination vaccines will simplify the implementation of effective vaccination programs.
S. pneumoniae is a major cause of (severe) respiratory infections and invasive pneumococcal disease (IPD). Pneumococcal conjugate vaccines (PCV) have been able to reduce the burden of disease in the particularly affected group of infants and young children. In addition to a relevant community immunity (“herd effect”), the increase in serotypes (ST) not contained in the vaccines had to be observed (“replacement”). New, higher-valent PCV 15 and 20 were developed.
Schlüsselwörter
Meningokokkenimpfstoffe - invasive Menigokokken-Infektionen - Meningokokken- und Pneumokokken-Impfprogramme - IPD - Pneumokokken-ImpfstoffeKeywords
Meningococcal vaccines - invasive meningococcal infections - meningococcal and pneumococcal vaccination programs - IPD - pneumococcal vaccinesPublication History
Article published online:
12 June 2023
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Literatur
- 1 Rosenstein NE. et al Medical Progress: Meningococcal Disease. N Engl J Med 2001; 344: 1378-1388
- 2 Knuf M.. Klinik der Meningokokken-Erkrankungen Kinderärztliche Praxis. 2021; 92: 3-5
- 3 Tenenbaum T. et al Meningokokken-Infektionen. In: DGPI-Handbuch, 7. vollständig überarbeitete Aufl. Stuttgart: Thieme Verlag; 2018
- 4 Huang L. et al Clinical and economic burden of invasive meningococcal disease: Evidence from a large German claims database. PLoS One 2020; 15 (01) e0228020
- 5 Thompson MJ. et al Clinical recognition of meningococcal disease in children and adolescents. Lancet 2006; 367: 397-403
- 6 Nürnberger W. et al Hautblutungen und Prognose bei systemischen Infektionen durch Neisseria meningitidis in Deutschland. Monatschr Kinderheilkd 1996; 144 (12) 1330-1336
- 7 Mayatepek E. et al Deafness, complement deficiencies and immunoglobulin status in patients with meningococcal diseases due to uncommon serogroups. Pediatr Infect Dis J 1993; 12 (10) 808-811
- 8 Huang L. et al Clinical and economic burden of invasive meningococcal disease: Evidence from a large German claims database. PLoS One 2020; 15 (01) e0228020
- 9 Lâm TT. et al Epidemiologischer Wandel der Meningokokken-Erkrankungen. Kinderärztliche Praxis 2021; 92: 6-10
- 10 Robert-Koch-Institut. Infektiologisches Jahrbuch meldepflichtiger Krankheiten für 2019 www.rki.de
- 11 Robert-Koch-Institut. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten für 2020 www.rki.de
- 12 Robert-Koch-Institut: SurvStat@RKI 2.0. https://survstat.rki.de Stand 02.03.2020, Übermittelte Fallzahlen invasiver Meningokokken-Erkrankungen gemäß Referenzdefinition; Meldepflicht gemäß IfSG; 2019; IME mit Angabe der Serogruppe B, C, W, Y
- 13 https://www.hygiene.uni-wuerzburg.de/meningococcus/nationales-referenzzentrum-fuer-meningokokken-und-haemophilus-influenzae/berichte/berichte-meningokokken/
- 14 Campbell H. et al Euro Surveill. 2015; 20 (28) pii = 21188
- 15 n. n. Invasive meningococcal disease in England: annual laboratory confirmed reports for epidemiological year 2018/2019. Health Protection Report Volume 13 Number 38. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/842368/hpr3819_IMD-ann.pdf zuletzt aufgerufen am 11.5.2023
- 16 Knol MJ. et al Implementation of MenACWY vaccination because of ongoing increase in serogroup W invasive meningococcal disease, the Netherlands, 2018. Euro Surveill 2018; 23 (16) pii = 18-00158
- 17 Gruhn S. et al Epidemiology and economic burden of meningococcal disease in Germany: A systematic review. Vaccine 2022; 18 (40) 13 1932-1947
- 18 n. n. Empfehlungen der Ständigen Impfkommission beim Robert Koch-Institut. Epidemiologisches Bulletin 2023; 4
- 19 Köllges R. Impfprävention. Aktuelle Studiendaten und Anwendung in der Praxis. Kinderärztliche Praxis 2021; 92: 15-18
- 20 Campbell H. et al Meningococcal C conjugate vaccine: The experience in England and Wales. Vaccine 2009; 27 (Suppl. 02) B20-29
- 21 Trotter CL. et al Meningococcal serogroup C conjugate vaccination in England and Wales: Coverage and initial impact of the campaign. Commun Dis Public Health 2002; 05 (03) 220-225
- 22 de Greeff SC. et al The first effect of the national vaccination campaign against meningococcal-C disease: A rapid and sharp decrease in the number of patients. Ned Tijdschr Geneeskd 2003; 147 (23) 1132-1135
- 23 Findlow J, Knuf M.. Immunogenicity and safety of meningococcal group A, C, W and Y tetanus toxoid conjugate vaccine: review of clinical and real-world evidence. Future Microbiol. 2019
- 24 Knuf M. et al Meningococcal serogroup C (MenC) immune response of a novel tetanus toxoid conjugate quadrivalent meningococcal vaccine (MenACYW-TT) compared to a quadrivalent (MCV4-TT) or monovalent (MenC-TT) meningococcal vaccine in healthy meningococcal vaccine-naïve toddlers. 31st ECCMID, late breaking clinical trial data session (code: S182). 10 July 2021
- 25 https://www.rivm.nl/meningokokken/toename-meningokokkenziekte-serogroep-w-sinds-oktober-2015
- 26 Findlow J. et al Broad vaccine protection against Neisseria meningitidis using factor H binding protein. Vaccine 2020; 38: 7716-7727
- 27 MenB-fHbp European Summary of Product Characteristics. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004051/WC500228995.pdf Stand: 11.5.2023
- 28 Wang X. et al Prevalence and genetic diversity of candidate vaccine antigens among invasive Neisseria meningitidis isolates in the United States. Vaccine 2011; 29: 4739-4744
- 29 Fachinformation Trumenba, Mai 2021
- 30 Østergaard L. et al Persistence of hSBA titers elicited by the meningococcal serogroup B vaccine menB-FHbp for up to 4 years after a 2- or 3-dose primary series and immunogenicity, safety, and tolerability of a booster dose through 26 months. Vaccine 2021; 39: 4545-4554
- 31 Fachinformation Bexsero, Juli 2020
- 32 Martinón-Torres F. et al Persistence of the immune response after 4CMenB vaccination, and the response to an additional booster dose in infants, children, adolescents, and young adults. Human Vaccines and Immunotherapeutics 2019; 15: 2940-2951
- 33 INSPQ. Impact épidémiologique de la campagne de vaccination contre le méningocoque de sérogroupe B dans la région du Saguenay–Lac-Saint-Jean, en 2014: rapport au 30 juin 2018, January 2019 https://www.inspq.qc.ca/publications/2491
- 34 Deceuninck G. et al Impact of a mass vaccination campaign against Serogroup B meningococcal disease in the Saguenay-Lac-Saint-Jean region of Quebec four years after its launch. Vaccine 2019; 37: 4243-4245
- 35 Ladhani SN. et al Vaccination of Infants with Meningococcal Group B Vaccine (4CMenB) in England. N Engl J Med 2020; 382: 309-317
- 36 Bryan P. et al Safety of multicomponent meningococcal group B vaccine (4CMenB) in routine infant immunisation in the UK: a prospective surveillance study. Lancet Child Adolesc Health 2018; 02: 395-403
- 37 Azzari C. et al Effectiveness and Impact of the 4CMenB Vaccine against Group B Meningococcal Disease in Two Italian Regions Using Different Vaccination Schedules: A Five-Year Retrospective Observational Study 2014–2018. Vaccines 2020; 08 (03) 469
- 38 Rodrigues F. et al Association of Use of a Meningococcus Group B Vaccine with Group B Invasive Meningococcal Disease Among Children in Portugal. JAMA 2020; 324 (21) 2187-2194
- 39 Marshall HS eta la. Meningococcal B Vaccine and Meningococcal Carriage in Adolescents in Australia. N Engl J Med 2020; 382: 318-327
- 40 McMillan M. et al Impact of Meningococcal B (4CMenB) Vaccine on Pharyngeal Neisseria meningitidis Carriage Density and Persistence in Adolescents. Clin Infect Dis 2021; 73: e99-e106
- 41 Marshall HS. et al Safety of meningococcal B vaccine (4CMenB) in adolescents in Australia. Vaccine 2020; 38: 5914-5922
- 42 Castilla J. et al Effectiveness of a Meningococcal Group B Vaccine (4CMenB) in Children. N Engl J Med 2023; 388 (05) 427-438
- 43 Ladhani SN. et al Effectiveness of Meningococcal B Vaccine against Endemic Hypervirulent Neisseria meningitidis W Strain, England. Emerg Infect Dis 2016; 22: 309-311
- 44 Tapia MD. et al Meningococcal Serogroup ACWYX Conjugate Vaccine in Malian Toddlers. N Engl J Med 2021; 384: 2115-2123
- 45 Chen WH. et al Safety and immunogenicity of a pentavalent meningococcal conjugate vaccine containing serogroups A, C, Y, W, and X in healthy adults. Lancet Infect Dis 2018; 18: 1088-1096 Epub 2018 Aug 14
- 46 Welsch JA. et al Breadth of coverage against a panel of 110 invasive disease isolates, immunogenicity and safety for 2 and 3 doses of an investigational MenABCWY vaccine in US adolescents. Vaccine 2018; 36: 5309-5317
- 47 Sáez-Llorens X. et al Four-year antibody persistence and response to a booster dose of a pentavalent MenABCWY vaccine administered to healthy adolescents and young adults. Hum Vaccin Immunother 2018; 14: 1161-1174
- 48 Szenborn L. et al Immune Responses to Booster Vaccination With Meningococcal ABCWY Vaccine After Primary Vaccination With Either Investigational or Licensed Vaccines: A Phase 2 Randomized Study. Pediatr Infect Dis J 2018; 37: 475-482
- 49 Saez-Llorens X. et al Persistence of Meningococcal Antibodies and Response to a Third Dose After a Two-dose Vaccination Series with Investigational MenABCWY Vaccine Formulations in Adolescents. Pediatr Infect Dis J 2015; 34: e264-278
- 50 Saez-Llorens X. et al Immunogenicity and safety of investigational vaccine formulations against meningococcal serogroups A, B, C, W, and Y in healthy adolescents. Hum Vaccin Immunother 2015; 11: 1507-1517
- 51 Block SL. et al A comparative evaluation of two investigational meningococcal ABCWY vaccine formulations: Results of a phase 2 randomized, controlled trial. Vaccine 2015; 33: 2500-2510
- 52 Ladhani S. et al Killing 2 Cocci With 1 Vaccine: Unleashing the Full Potential of an Adolescent Meningococcal B Immunization Program. Clin Inf Dis 2021; 73: e238-240
- 53 DGPI-Handbuch Infektionen bei Kindern und Jugendlichen, 7. Aufl. Stuttgart: Thieme-Verlag; 2018
- 54 van der Linden M. et al Limited indirect effects of an infant pneumococcal vaccination program in an aging population. PLoS One 2019; 14 (08) e0220453
- 55 Pelton SL. et al Rates of pneumonia among children and adults with chronic medical conditions in Germany. BMC Infect Dis 2015; 15: 470
- 56 Hu T. et al Incidence of acute otitis media in children < 16 years old in Germany during 2014–2019. BMC Pediatr 2022; 22 (01) 204
- 57 Pelton SL. The challenge of preventing invasive pneumococcal disease in children with comorbid illnesses. Clin Infect Dis 2014; 58 (04) 526-527
- 58 Musher D. et al The remarkable history of pneumococcal vaccination: an ongoing cjhallenge. Penumonia 2022; 14: 5
- 59 de Wals P. et al Incidence of invasive pneumococcal disease before and during an era of use of three different pneumococcal conjugate vaccines in Quebec. Vaccine 2018; 36 (03) 421-426
- 60 Robert Koch-Institut (RKI) 2022. Schutzimpfung gegen Pneumokokken: Häufig gestellte Fragen und Antworten. Stand: 23.06.2020. https://www.rki.de/SharedDocs/FAQ/Impfen/Pneumokokken/FAQ-Liste_Pneumokokken_Impfen.html (eingesehen am 11.5.2023)
- 61 Robert Koch-Institut (RKI) Empfehlungen der Ständigen Impfkommission (STIKO) am RKI. Epid Bull 2016; 36: 351-384
- 62 Knoll M. et al Global Landscape Review of Serotype-Specific Invasive Pneumococcal Disease Surveillance among Countries Using PCV10/13: The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) Project. Microorganisms 2021; 09 (04) 742
- 63 Goettler, et al Increase in Streptococcus pneumonia serotype 3 associated parapneumonic pleural effusion/empyema after the introduction of PCV13 in Germany. Vaccine 2020; 38: 570-577
- 64 Luck JN. et al Sugar-Coated Killer: Serotype 3 Pneumococcal Disease. Front Cell Infect Microbiol 2020; 10: 613287
- 65 Akhter F. et al Hemoglobin Induces Early and Robust Biofilm Development in Streptococcus pneumoniae by a Pathway That Involves comC but Not the Cognate comDE Two-Component System. Infect Immun 2021; 89 (04) e00779-20
- 66 Weinberger R. et al Invasive pneumococcal disease in children under 16 years of age: Incomplete rebound in incidence after the maximum effect of PCV13 in 2012/13 in Germany. Vaccine 2018; 25 36 (04) 572-577
- 67 Sempere J. et al Clinical Relevance and Molecular Pathogenesis of the Emerging Serotypes 22 F and 33 F of Streptococcus pneumoniae in Spain. Front Microbiol 2020; 11: 309
- 68 Golden AR. et al Whole genome characterization of Streptococcus pneumoniae from respiratory and blood cultures collected from Canadian hospitals before and after PCV-13 implementation in Canada. Vaccine 2021; 39 (39) 5474-5483
- 69 Balsells E. et al Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: a systematic review and meta-analysis. PLoS One 2017; 12 (05) e0177113
- 70 Adebanjo TA. et al Pneumococcal Conjugate Vaccine Breakthrough Infections: 2001–2016. Pediatrics 2020; 145 (03) e20190836
- 71 Perniciaro S. et al Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021. Clin Infect Dis 2022; 75 (07) 1149-1153
- 72 Fachinformation VAXNEUVANCE®
- 73 Martinon-Torres F. et al Phase 3 Study of Safety, Tolerability and Immunogenicity of V114 Compared with PCV13 In 2 + 1 Regimen in Healthy Infants (PNEU-PED-EU-1). ESPID 2022
- 74 Essink B. et al Pivotal Phase 3 Randomised Clinical Trial of the Safety, Tolerability, and Immunogenicity of 20-Valent Pneumococcal Conjugate Vaccine in Adults 18 Years and Older. Clin Infect Dis 2021; 23: ciab990
- 75 https://www.businesswire.com/news/home/20220919005238/en/Pfizer-Announces-Positive-Top-Line-Results-from-Phase-3-Study-in-20-Valent-Pneumococcal-Conjugate-Vaccine-in-Infants-in-the-European-Union
- 76 Mt-Isa S. et al Matching-adjusted indirect comparison of pneumococcal vaccines V114 and PCV20. Expert Rev vaccines 2022; 21: 115-123
- 77 Chichili GR. Phase 1/2 study of a novel 24-valent pneumococcal vaccine in healthy adults aged 18 to 64 years and in older adults aged 65 to 85 years. Vaccine 2022; 40 (31) 4190-4198
- 78 Stellungnahme der STIKO zum Einsatz von Pneumokokken-Konjugatimpfstoffen im Säuglings-, Kindes- und Jugendalter. Epidemiolgisches Bulletin 2023; 20