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CC BY 4.0 · SynOpen 2023; 07(02): 145-153
DOI: 10.1055/a-2063-4139
paper
Virtual Collection Click Chemistry and Drug Discovery

Synthesis of Calix[4]arene Appended Lactosylated G1 and Galacto­sylated G2 Generation Glycodendrimers using a ‘CuAAC’ Click Approach

Sunil Kumar
a   Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India
,
Mangal S. Yadav
a   Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India
,
Sumit K. Singh
a   Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India
,
Sanchayita Rajkhowa
b   Department of Chemistry, The Royal Global University, Guwahati-781035, Assam, INDIA
,
Vinod K. Tiwari  ∗
a   Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India
› Author AffiliationsThe authors gratefully acknowledge the Science and Engineering Research Board (Grant No.: CRG/2021/002776) for the funding. V.K.T. acknowledges the Institute of Eminence (IoE)-Banaras Hindu University for the incentive grant. S.K., M.S.Y., and S.K.S. sincerely acknowledge UGC-CSIR New Delhi for Senior Research Fellowships (SRF).

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This manuscript is dedicated to (Late) Prof. Alan R. Katritzky for his contributions to benzotriazole chemistry.

Abstract

A modular and highly reliable click approach is applied for the expeditious synthesis of lactose- and galactose-coated calixarene-cored G1 and G2 generation glycodendrimers, respectively. The developed calixarene glycodendrimers have been characterized by using extensive spectral analysis including NMR (1H and 13C), MS, IR, and SEC data.

Key words

azide - alkyne - click reaction - calix[4]arene - macrocyclic - glycodendrimer - catalysis

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2063-4139. Copies of 1H and 13C NMR for all the developed compounds for this article are available.
  • Supporting Information


Publication History

Received: 31 January 2023

Accepted after revision: 27 March 2023

Accepted Manuscript online:
28 March 2023

Article published online:
24 April 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

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