The Perioperative Application of Tranexamic Acid

Zusammenfassung

Der Einsatz von Tranexamsäure (TXA) hat in den letzten Jahren bei der Durchführung endoprothetischer Operationen stark zugenommen. Die Möglichkeit, den Blutverlust zu reduzieren, die Zahl der Transfusionen zu vermindern und meist auf Drainagen zu verzichten, lassen den Einsatz von TXA immer mehr als „Standard“ erscheinen. Andererseits besteht keine Zulassung von TXA für den Einsatz bei endoprothetischen Eingriffen. Aus diesem Grund sollte unbedingt immer einen Nutzen-Risiko-Analyse erfolgen. Eine prophylaktische TXA-Gabe ohne Aufklärung ist daher gerechtfertigt, wenn eine fibrinolysebedingte Blutung zu erwarten ist und keine Kontraindikationen oder Risikofaktoren für thromboembolische Komplikationen vorliegen. Eine Aufklärung ist auch nicht erforderlich, wenn im Rahmen einer fibrinolysebedingten Blutung eine therapeutische TXA-Gabe erfolgt. Der nach gegenwärtigem Kenntnisstand optimale Zeitpunkt, die möglichen Applikationswege und die Dosierungsempfehlungen werden in der vorliegenden Handlungsempfehlung dargestellt.

Schlüsselwörter

Tranexamsäure - Fibrinolyse - Hyperfibrinolyse - Blutverlust

Publikationsverlauf

Artikel online veröffentlicht:
19. Juni 2023

• Literatur

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