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CC BY 4.0 · SynOpen 2023; 07(02): 165-185
DOI: 10.1055/a-2048-8412
DOI: 10.1055/a-2048-8412
graphical review
Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery
Generous financial support from the National Institutes of Health (NIH) is gratefully acknowledged (National Institute of General Medical Sciences – Grant No. R35GM128621) to R.W.H. D.A.L. was supported by the T-32 Team-Based Interdisciplinary Cancer Research Training (TICaRT) program at the University of Florida Health Cancer Center (T32 CA257923).
Abstract
This graphical review provides a concise overview of indole alkaloids and chemical reactions that have been reported to transform both these natural products and derivatives to rapidly access new molecular scaffolds. Select biologically active compounds from these synthetic efforts are reported herein.
Keywords
indole alkaloids - yohimbine - vincamine - reserpine - chemical synthesis - ring distortionPublication History
Received: 31 January 2023
Accepted: 07 March 2023
Accepted Manuscript online:
07 March 2023
Article published online:
11 May 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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