Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives

Abstract

Linearly fused retinoid derivatives have been synthesized via a straightforward pathway using a palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four-step linear approach utilizing iodination, sulfonylation or benzylation or esterification, palladium-catalyzed Sonogashira cross-coupling and palladium-mediated reductive Heck cyclization.

Key words

retinoids - Heck - Sonogashira - cross-coupling

Publication History

Received: 17 December 2022

Accepted after revision: 30 January 2023

Accepted Manuscript online:
30 January 2023

Article published online:
15 February 2023

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