Subscribe to RSS
DOI: 10.1055/a-2015-3821
Erkenntnisse der Gendermedizin – Relevanz für die Chirurgie?
Einleitung
Auf den ersten Blick erscheinen einem die geschlechtsspezifischen Unterschiede in Verbindung mit relevanten Folgen für chirurgische Eingriffe trivial. Natürlich gibt es anatomische Unterschiede, die Chirurgen*innen anscheinend kein besonderes Wissen abverlangen. Weit gefehlt! Diagnostik, Pathogenese, Therapie und Prävention von Erkrankungen können sich geschlechtsspezifisch deutlich voneinander unterscheiden. Deshalb haben sich in der Zwischenzeit geschlechtssensible Lehrinhalte in die medizinischen Curricula implementiert. Sexualhormone und Genexpressionen auf den unterschiedlichen X- und Y-Chromosomen sowie die soziokulturellen Unterschiede haben nachweislich Einfluss auf Krankheitsmuster und -schwere. Das Zusammenspiel beider Komponenten scheint ein wesentlicher Faktor in der Entwicklung von Krankheiten zu sein. Dies hat auch Einfluss auf den postoperativen Verlauf mit einer erhöhten Rate an postoperativen Komplikationen bei Männern und einem höheren Schmerzempfinden bei Frauen.
Publication History
Article published online:
23 February 2023
© 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Baggish MS, Karram MM. Atlas of pelvic Anatomy and gynecologic Surgery. 4th. Elsevier Health Sciences; 2015
- 2 De Francesco MA, Stefanelli P, Carannante A. et al. Management of a Case of Peritonitis Due to Neisseria gonorrhoeae Infection Following Pelvic Inflammatory Disease (PID). Antibiotics (Basel) 2020; 9: 193 DOI: 10.3390/antibiotics9040193. (PMID: 32325724)
- 3 Lopes de Sousa Martins PA. Experimental and Numerical Studies of Soft Biological Tissues [Dissertation]. Porto: Universidade do Porto; 2010. Accessed January 23, 2023 at: https://www.researchgate.net/publication/216453509_Experimental_and_Numerical_Studies_of_Soft_Biological_Tissues
- 4 Moszkowicz D, Alsaid B, Bessede T. et al. Where does pelvic nerve injury occur during rectal surgery for cancer?. Colorectal Dis 2011; 13: 1326-1334 DOI: 10.1111/j.1463-1318.2010.02384.x. (PMID: 20718836)
- 5 Schünke M, Schulte E, Schumacher U, Voll M, Wesker K. Prometheus – LernAtlas der Anatomie, Innere Organe. 5. Stuttgart: Thieme; 2018
- 6 Lee SY, Kang SB, Kim DW. et al. Risk Factors and Preventive Measures for Acute Urinary Retention after Rectal Cancer Surgery. World J Surg 2015; 39: 275-282 DOI: 10.1007/s00268-014-2767-9. (PMID: 25189452)
- 7 Eveno C, Lamblin A, Mariette C. et al. Sexual and urinary dysfunction after proctectomy for rectal cancer. J Visc Surg 2010; 147: e21-e30 DOI: 10.1016/j.jviscsurg.2010.02.001. (PMID: 20587375)
- 8 Mundy AR. An anatomical explanation for bladder dysfunction following rectal and uterine surgery. Br J Urol 1982; 54: 501-504 DOI: 10.1111/j.1464-410x.1982.tb13575.x. (PMID: 7171956)
- 9 Croese AD, Lonie JM, Trollope AF. et al. A meta-analysis of the prevalence of Low Anterior Resection Syndrome and systematic review of risk factors. Int J Surg 2018; 56: 234-241 DOI: 10.1016/j.ijsu.2018.06.031. (PMID: 29936195)
- 10 Dulskas A, Kavaliauskas P, Kulikauskas E. et al. Low Anterior Resection Syndrome: What Have We Learned Assessing a Large Population?. J Clin Med 2022; 11: 4752 DOI: 10.3390/jcm11164752. (PMID: 36012991)
- 11 Lange MM, Maas CP, Marijnen CA. et al. Urinary dysfunction after rectal cancer treatment is mainly caused by surgery. Br J Surg 2008; 95: 1020-1028 DOI: 10.1002/bjs.6126. (PMID: 18563786)
- 12 Ruhl CE, Everhart JE. Risk factors for inguinal hernia among adults in the US population. Am J Epidemiol 2007; 165: 1154-1161 DOI: 10.1093/aje/kwm011. (PMID: 17374852)
- 13 Kingsnorth A, LeBlanc K. Hernias: inguinal and incisional. Lancet 2003; 362: 1561-1571 DOI: 10.1016/s0140-6736(03)14746-0. (PMID: 14615114)
- 14 Dahlstrand U, Wollert S, Nordin P. et al. Emergency femoral hernia repair: a study based on a national register. Ann Surg 2009; 249: 672-676 DOI: 10.1097/SLA.0b013e31819ed943. (PMID: 19300219)
- 15 Nilsson H, Holmberg H, Nordin P. Groin hernia repair in women – a nationwide register study. Am J Surg 2018; 216: 274-279 DOI: 10.1016/j.amjsurg.2017.07.027. (PMID: 28784237)
- 16 Thairu NM, Heather BP, Earnshaw JJ. Open inguinal hernia repair in women: is mesh necessary?. Hernia 2008; 12: 173-175 DOI: 10.1007/s10029-007-0306-4. (PMID: 17999127)
- 17 Cherla DV, Poulose B, Prabhu AS. Epidemiology and Disparities in Care: The Impact of Socioeconomic Status, Gender, and Race on the Presentation, Management, and Outcomes of Patients Undergoing Ventral Hernia Repair. Surg Clin North Am 2018; 98: 431-440 DOI: 10.1016/j.suc.2018.02.003. (PMID: 29754613)
- 18 Shen MR, Howard R, Ehlers AP. et al. Ventral hernia repair and mesh use in females of childbearing age. Surg Endosc 2022; DOI: 10.1007/s00464-022-09429-x. (PMID: 35927347)
- 19 Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol 1975; 93: 639-643 DOI: 10.1111/j.1365-2133.1975.tb05113.x. (PMID: 1220811)
- 20 Lenhardt R, Hopf HW, Marker E. et al. Perioperative collagen deposition in elderly and young men and women. Arch Surg 2000; 135: 71-74 DOI: 10.1001/archsurg.135.1.71. (PMID: 10636351)
- 21 van Ramshorst GH, Nieuwenhuizen J, Hop WC. et al. Abdominal wound dehiscence in adults: development and validation of a risk model. World J Surg 2010; 34: 20-27 DOI: 10.1007/s00268-009-0277-y. (PMID: 19898894)
- 22 Lephart ED, Naftolin F. Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs). Clin Cosmet Investig Dermatol 2022; 15: 1695-1709 DOI: 10.2147/ccid.S333663. (PMID: 36017417)
- 23 Pelekanou V, Kampa M, Kiagiadaki F. et al. Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1. J Leukoc Biol 2016; 99: 333-347 DOI: 10.1189/jlb.3A0914-430RR. (PMID: 26394816)
- 24 Taneja V. Sex Hormones Determine Immune Response. Front Immunol 2018; 9: 1931 DOI: 10.3389/fimmu.2018.01931. (PMID: 30210492)
- 25 Romana-Souza B, Assis de Brito TL, Pereira GR. et al. Gonadal hormones differently modulate cutaneous wound healing of chronically stressed mice. Brain Behav Immun 2014; 36: 101-110 DOI: 10.1016/j.bbi.2013.10.015.
- 26 Ashcroft GS, Dodsworth J, van Boxtel E. et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med 1997; 3: 1209-1215 DOI: 10.1038/nm1197-1209. (PMID: 9359694)
- 27 Ashcroft GS. Sex Differences in Wound Healing. Advances in Molecular and Cell Biology. Elsevier; 2004. Accessed January 23, 2023 at: https://doi.org/10.1016/S1569-2558(03)34022-6
- 28 Jansson G. Oestrogen-Induced Enhancement of Myeloperoxidase Activity in Human Polymorphonuclear Leukocytes-A Possible Cause of Oxidative Stress in Inflammatory Cells. Free Radic Res Commun 1991; 14: 195-208 DOI: 10.3109/10715769109088949. (PMID: 1648023)
- 29 Langelotz C, Mueller-Rau C, Terziyski S. et al. Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System. Viszeralmedizin 2014; 30: 114-117 DOI: 10.1159/000362100. (PMID: 26288585)
- 30 Aghdassi SJS, Schröder C, Gastmeier P. Gender-related risk factors for surgical site infections. Results from 10 years of surveillance in Germany. Antimicrob Resist Infect Control 2019; 8: 95 DOI: 10.1186/s13756-019-0547-x. (PMID: 31171966)
- 31 Berkley KJ. Vive la différence!. Trends Neurosci 1992; 15: 331-332 DOI: 10.1016/0166-2236(92)90048-d. (PMID: 1382330)
- 32 Ruda MA. Gender and pain. Pain 1993; 53: 1-2 DOI: 10.1016/0304-3959(93)90048-t. (PMID: 8316380)
- 33 Mowlavi A, Cooney D, Febus L. et al. Increased cutaneous nerve fibers in female specimens. Plast Reconstr Surg 2005; 116: 1407-1410 DOI: 10.1097/01.prs.0000182339.83156.06. (PMID: 16217487)
- 34 Craft RM. Modulation of pain by estrogens. Pain 2007; 132 (Suppl. 01) S3-S12 DOI: 10.1016/j.pain.2007.09.028. (PMID: 17951003)
- 35 Mogil JS. Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon. Nat Rev Neurosci 2012; 13: 859-866 DOI: 10.1038/nrn3360. (PMID: 23165262)
- 36 Pereira MP, Pogatzki-Zahn E. Gender aspects in postoperative pain. Curr Opin Anaesthesiol 2015; 28: 546-558 DOI: 10.1097/aco.0000000000000226. (PMID: 26308516)
- 37 Hussain AM, Khan FA, Ahmed A. et al. Effect of gender on pain perception and analgesic consumption in laparoscopic cholecystectomy: An observational study. J Anaesthesiol Clin Pharmacol 2013; 29: 337-341 DOI: 10.4103/0970-9185.117095. (PMID: 24106358)
- 38 Fillingim RB, Gear RW. Sex differences in opioid analgesia: clinical and experimental findings. Eur J Pain 2004; 8: 413-425 DOI: 10.1016/j.ejpain.2004.01.007. (PMID: 15324773)
- 39 Niesters M, Dahan A, Kest B. et al. Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain 2010; 151: 61-68 DOI: 10.1016/j.pain.2010.06.012. (PMID: 20692097)
- 40 Liem MSL, van der Graaf Y, Zwart RC. et al. Risk Factors for Inguinal Hernia in Women: A Case-Control Study. Am J Epidemiol 1997; 146: 721-726 DOI: 10.1093/oxfordjournals.aje.a009347. (PMID: 9366619)
- 41 Oma E, Henriksen NA, Jensen KK. Ventral hernia and pregnancy: A systematic review. Am J Surg 2019; 217: 163-168 DOI: 10.1016/j.amjsurg.2018.04.016. (PMID: 29798763)
- 42 Davis JL, Buchanan KL, Katz RV. et al. Gender differences in cancer screening beliefs, behaviors, and willingness to participate: implications for health promotion. Am J Mens Health 2012; 6: 211-217 DOI: 10.1177/1557988311425853. (PMID: 22071507)
- 43 White A, Ironmonger L, Steele RJC. et al. A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK. BMC Cancer 2018; 18: 906 DOI: 10.1186/s12885-018-4786-7. (PMID: 30236083)
- 44 Yang Y, Wang G, He J. et al. Gender differences in colorectal cancer survival: A meta-analysis. Int J Cancer 2017; 141: 1942-1949 DOI: 10.1002/ijc.30827. (PMID: 28599355)
- 45 Abancens M, Bustos V, Harvey H. et al. Sexual Dimorphism in Colon Cancer. Front Oncol 2020; 10: 607909 DOI: 10.3389/fonc.2020.607909. (PMID: 33363037)